Binary switch activity of the Tat peptide

from membrane penetration to lytic action

Stefania Piantavigna, Muhammad Abdelhamid, C Zhao, Xiaohu Qu, Bimbil Graham, Leone Spiccia, Anthony O'Mullane, Lisandra Lorraine Martin

Research output: Contribution to conferencePosterOther

Abstract

Tat peptides are considered to be cell-penetrating peptides(CCPs). They are derived from the HIV-1 virus where they contain the basic RNA-binding domain of the Tat protein (YGRKKRRQRRR). This domain confers the ability membrane penetration to these peptides. One advantage of Tat is that it can be modified by covalent attachment of delivery of cargo to intracellular sites, i.e. drug delivery. However, the mechanism by which these CPPs translocate to the cytoplasm is still contentious. One advantage of Tat peptides is that they can be used in potential therapeutical applications such as: cargo peptide for drug delivery and antimicrobial peptide (AMP), as they exhibit antifungal and antibacterial properties,
Original languageEnglish
PagesS80-S80
Number of pages1
Publication statusPublished - 2012

Cite this

Piantavigna, S., Abdelhamid, M., Zhao, C., Qu, X., Graham, B., Spiccia, L., ... Martin, L. L. (2012). Binary switch activity of the Tat peptide: from membrane penetration to lytic action. S80-S80.
Piantavigna, Stefania ; Abdelhamid, Muhammad ; Zhao, C ; Qu, Xiaohu ; Graham, Bimbil ; Spiccia, Leone ; O'Mullane, Anthony ; Martin, Lisandra Lorraine. / Binary switch activity of the Tat peptide : from membrane penetration to lytic action. 1 p.
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title = "Binary switch activity of the Tat peptide: from membrane penetration to lytic action",
abstract = "Tat peptides are considered to be cell-penetrating peptides(CCPs). They are derived from the HIV-1 virus where they contain the basic RNA-binding domain of the Tat protein (YGRKKRRQRRR). This domain confers the ability membrane penetration to these peptides. One advantage of Tat is that it can be modified by covalent attachment of delivery of cargo to intracellular sites, i.e. drug delivery. However, the mechanism by which these CPPs translocate to the cytoplasm is still contentious. One advantage of Tat peptides is that they can be used in potential therapeutical applications such as: cargo peptide for drug delivery and antimicrobial peptide (AMP), as they exhibit antifungal and antibacterial properties,",
author = "Stefania Piantavigna and Muhammad Abdelhamid and C Zhao and Xiaohu Qu and Bimbil Graham and Leone Spiccia and Anthony O'Mullane and Martin, {Lisandra Lorraine}",
year = "2012",
language = "English",
pages = "S80--S80",

}

Piantavigna, S, Abdelhamid, M, Zhao, C, Qu, X, Graham, B, Spiccia, L, O'Mullane, A & Martin, LL 2012, 'Binary switch activity of the Tat peptide: from membrane penetration to lytic action' pp. S80-S80.

Binary switch activity of the Tat peptide : from membrane penetration to lytic action. / Piantavigna, Stefania; Abdelhamid, Muhammad; Zhao, C; Qu, Xiaohu; Graham, Bimbil; Spiccia, Leone; O'Mullane, Anthony; Martin, Lisandra Lorraine.

2012. S80-S80.

Research output: Contribution to conferencePosterOther

TY - CONF

T1 - Binary switch activity of the Tat peptide

T2 - from membrane penetration to lytic action

AU - Piantavigna, Stefania

AU - Abdelhamid, Muhammad

AU - Zhao, C

AU - Qu, Xiaohu

AU - Graham, Bimbil

AU - Spiccia, Leone

AU - O'Mullane, Anthony

AU - Martin, Lisandra Lorraine

PY - 2012

Y1 - 2012

N2 - Tat peptides are considered to be cell-penetrating peptides(CCPs). They are derived from the HIV-1 virus where they contain the basic RNA-binding domain of the Tat protein (YGRKKRRQRRR). This domain confers the ability membrane penetration to these peptides. One advantage of Tat is that it can be modified by covalent attachment of delivery of cargo to intracellular sites, i.e. drug delivery. However, the mechanism by which these CPPs translocate to the cytoplasm is still contentious. One advantage of Tat peptides is that they can be used in potential therapeutical applications such as: cargo peptide for drug delivery and antimicrobial peptide (AMP), as they exhibit antifungal and antibacterial properties,

AB - Tat peptides are considered to be cell-penetrating peptides(CCPs). They are derived from the HIV-1 virus where they contain the basic RNA-binding domain of the Tat protein (YGRKKRRQRRR). This domain confers the ability membrane penetration to these peptides. One advantage of Tat is that it can be modified by covalent attachment of delivery of cargo to intracellular sites, i.e. drug delivery. However, the mechanism by which these CPPs translocate to the cytoplasm is still contentious. One advantage of Tat peptides is that they can be used in potential therapeutical applications such as: cargo peptide for drug delivery and antimicrobial peptide (AMP), as they exhibit antifungal and antibacterial properties,

M3 - Poster

SP - S80-S80

ER -

Piantavigna S, Abdelhamid M, Zhao C, Qu X, Graham B, Spiccia L et al. Binary switch activity of the Tat peptide: from membrane penetration to lytic action. 2012.