TY - CONF
T1 - Binary switch activity of the Tat peptide
T2 - from membrane penetration to lytic action
AU - Piantavigna, Stefania
AU - Abdelhamid, Muhammad
AU - Zhao, Chuan
AU - Qu, Xiaohu
AU - Graham, Bimbil
AU - Spiccia, Leone
AU - O'Mullane, Anthony
AU - Martin, Lisandra Lorraine
PY - 2012
Y1 - 2012
N2 - Tat peptides are considered to be cell-penetrating peptides(CCPs). They are derived from the HIV-1 virus where they contain the basic RNA-binding domain of the Tat protein (YGRKKRRQRRR). This domain confers the ability membrane penetration to these peptides. One advantage of Tat is that it can be modified by covalent attachment of delivery of cargo to intracellular sites, i.e. drug delivery. However, the mechanism by which these CPPs translocate to the cytoplasm is still contentious. One advantage of Tat peptides is that they can be used in potential therapeutical applications such as: cargo peptide for drug delivery and antimicrobial peptide (AMP), as they exhibit antifungal and antibacterial properties,
AB - Tat peptides are considered to be cell-penetrating peptides(CCPs). They are derived from the HIV-1 virus where they contain the basic RNA-binding domain of the Tat protein (YGRKKRRQRRR). This domain confers the ability membrane penetration to these peptides. One advantage of Tat is that it can be modified by covalent attachment of delivery of cargo to intracellular sites, i.e. drug delivery. However, the mechanism by which these CPPs translocate to the cytoplasm is still contentious. One advantage of Tat peptides is that they can be used in potential therapeutical applications such as: cargo peptide for drug delivery and antimicrobial peptide (AMP), as they exhibit antifungal and antibacterial properties,
U2 - 10.1002/psc.2449
DO - 10.1002/psc.2449
M3 - Poster
SP - S80-S80
ER -
