Binary switch activity of the Tat peptide: from membrane penetration to lytic action

Stefania Piantavigna, Muhammad Abdelhamid, Chuan Zhao, Xiaohu Qu, Bimbil Graham, Leone Spiccia, Anthony O'Mullane, Lisandra Lorraine Martin

Research output: Contribution to conferencePoster


Tat peptides are considered to be cell-penetrating peptides(CCPs). They are derived from the HIV-1 virus where they contain the basic RNA-binding domain of the Tat protein (YGRKKRRQRRR). This domain confers the ability membrane penetration to these peptides. One advantage of Tat is that it can be modified by covalent attachment of delivery of cargo to intracellular sites, i.e. drug delivery. However, the mechanism by which these CPPs translocate to the cytoplasm is still contentious. One advantage of Tat peptides is that they can be used in potential therapeutical applications such as: cargo peptide for drug delivery and antimicrobial peptide (AMP), as they exhibit antifungal and antibacterial properties,
Original languageEnglish
Number of pages1
Publication statusPublished - 2012

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