Bilateral thalamic high-grade astrocytomas in an early-adolescent child: A case report

Dion A. Paul; Emma Poon; Mithun Nambiar; Douglas Anderson

doi:10.1111/1754-9485.13620

Bilateral thalamic high-grade astrocytomas in an early-adolescent child: A case report

Dion A. Paul, Emma Poon, Mithun Nambiar, Douglas Anderson

Eastern Health Clinical School

Research output: Contribution to journal › Letter › Other › peer-review

Abstract

An early-adolescent girl presented with incoordination, headache, vomiting and dysphonia. MRI brain demonstrated diffuse increased T2 and FLAIR signal in bilateral thalami, consistent with anaplastic astrocytomas. A stereotactic burr-hole biopsy provided frozen tissues sections demonstrating an IDH-1 wildtype astrocytoma (anaplastic grade III according to prior WHO classification 2016-21). Chemoradiotherapy was commenced. Bilateral thalamic high-grade astrocytomas are very rare in the paediatric population and require timely diagnosis and interdisciplinary management. CT and MR imaging help point towards this diagnosis in the correct clinical context.

Original language	English
Pages (from-to)	167-170
Number of pages	4
Journal	Journal of Medical Imaging and Radiation Oncology
Volume	68
Issue number	2
DOIs	https://doi.org/10.1111/1754-9485.13620
Publication status	Published - Mar 2024

Keywords

astrocytoma
brain neoplasm
paediatric
thalamic enlargement

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title = "Bilateral thalamic high-grade astrocytomas in an early-adolescent child: A case report",

abstract = "An early-adolescent girl presented with incoordination, headache, vomiting and dysphonia. MRI brain demonstrated diffuse increased T2 and FLAIR signal in bilateral thalami, consistent with anaplastic astrocytomas. A stereotactic burr-hole biopsy provided frozen tissues sections demonstrating an IDH-1 wildtype astrocytoma (anaplastic grade III according to prior WHO classification 2016-21). Chemoradiotherapy was commenced. Bilateral thalamic high-grade astrocytomas are very rare in the paediatric population and require timely diagnosis and interdisciplinary management. CT and MR imaging help point towards this diagnosis in the correct clinical context.",

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T1 - Bilateral thalamic high-grade astrocytomas in an early-adolescent child

T2 - A case report

AU - Paul, Dion A.

AU - Poon, Emma

AU - Nambiar, Mithun

AU - Anderson, Douglas

N1 - Publisher Copyright: © 2024 The Authors. Journal of Medical Imaging and Radiation Oncology published by John Wiley & Sons Australia, Ltd on behalf of Royal Australian and New Zealand College of Radiologists.

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N2 - An early-adolescent girl presented with incoordination, headache, vomiting and dysphonia. MRI brain demonstrated diffuse increased T2 and FLAIR signal in bilateral thalami, consistent with anaplastic astrocytomas. A stereotactic burr-hole biopsy provided frozen tissues sections demonstrating an IDH-1 wildtype astrocytoma (anaplastic grade III according to prior WHO classification 2016-21). Chemoradiotherapy was commenced. Bilateral thalamic high-grade astrocytomas are very rare in the paediatric population and require timely diagnosis and interdisciplinary management. CT and MR imaging help point towards this diagnosis in the correct clinical context.

AB - An early-adolescent girl presented with incoordination, headache, vomiting and dysphonia. MRI brain demonstrated diffuse increased T2 and FLAIR signal in bilateral thalami, consistent with anaplastic astrocytomas. A stereotactic burr-hole biopsy provided frozen tissues sections demonstrating an IDH-1 wildtype astrocytoma (anaplastic grade III according to prior WHO classification 2016-21). Chemoradiotherapy was commenced. Bilateral thalamic high-grade astrocytomas are very rare in the paediatric population and require timely diagnosis and interdisciplinary management. CT and MR imaging help point towards this diagnosis in the correct clinical context.

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Bilateral thalamic high-grade astrocytomas in an early-adolescent child: A case report

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