Bidirectional transport of NMDA receptor and ionophore in the vagus nerve

Marion Cincotta, Philip M. Beart, Roger J. Summers, David Lodge

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Abstract

Accumulations of binding sites for [3H]3-((±)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic ([3HCPP) and [3H]-N-(1-[2-thienyl]cyclohexyl)-3,4-piperidine ([3H]TCP) were demonstrated both proximal and distal to 24-h ligatures of the central and peripheral vagus nerve in the rat using radioligand binding and autoradiography. Peaks of label occurred at the proximal and distal extremities of double ligations but not between the ligatures, or in sham-operated or colchicine-treated nerves. Together these results suggest that both the primary acceptor site and the ionophore of the N-methyl-D-aspartate receptor undergo bidirectional axonal transport in central and peripheral branches of the vagus nerve.

Original languageEnglish
Pages (from-to)167-171
Number of pages5
JournalEuropean Journal of Pharmacology
Volume160
Issue number1
DOIs
Publication statusPublished - 24 Jan 1989

Keywords

  • (Autoradiography)
  • Axonal transport
  • Ionophore complex
  • NMDA receptors

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