Biallelic inactivation of the RIZ1 gene in human gastric cancer

Yutaka Tokumaru; Shuji Nomoto; Carmen Jerónimo; Rui Henrique; Susan Harden; Barry Trink; David Sidransky

doi:10.1038/sj.onc.1206403

Biallelic inactivation of the RIZ1 gene in human gastric cancer

Yutaka Tokumaru
, Shuji Nomoto
, Carmen Jerónimo
, Rui Henrique
, Susan Harden
, Barry Trink
, David Sidransky

Research output: Contribution to journal › Article › Research › peer-review

55 Citations (Scopus)

Abstract

The distal short arm of chromosome 1 is commonly deleted in a variety of human neoplasms including gastrointestinal cancer. Genetic alterations of the retinoblastoma protein-interacting zing-finger gene (RIZ)1 including loss of heterozygosity (LOH) at 1p36, frameshift mutations, and promoter hypermethylation were reported previously in several cancers. In this study, we evaluated RIZ1 in 30 primary gastric cancers and found frameshift mutations in two cases (6.7%). Moreover, using real-time quantitative methylation-specific PCR, methylation of the RIZ1 promoter was detected in 11 (37%) cases. In all 11 cases with methylation, inactivation of the second allele occurred through frameshift mutation, LOH or promoter methylation. Our results suggest that RIZ1 is a specific target of inactivation in human gastric cancer.

Original language	English
Pages (from-to)	6954-6958
Number of pages	5
Journal	Oncogene
Volume	22
Issue number	44
DOIs	https://doi.org/10.1038/sj.onc.1206403
Publication status	Published - 9 Oct 2003
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Gastric cancer tumor suppressor gene
Gene silencing
Hypermethylation
RIZ1

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313586554-oaFinal published version, 260 KB

Cite this

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title = "Biallelic inactivation of the RIZ1 gene in human gastric cancer",

abstract = "The distal short arm of chromosome 1 is commonly deleted in a variety of human neoplasms including gastrointestinal cancer. Genetic alterations of the retinoblastoma protein-interacting zing-finger gene (RIZ)1 including loss of heterozygosity (LOH) at 1p36, frameshift mutations, and promoter hypermethylation were reported previously in several cancers. In this study, we evaluated RIZ1 in 30 primary gastric cancers and found frameshift mutations in two cases (6.7\%). Moreover, using real-time quantitative methylation-specific PCR, methylation of the RIZ1 promoter was detected in 11 (37\%) cases. In all 11 cases with methylation, inactivation of the second allele occurred through frameshift mutation, LOH or promoter methylation. Our results suggest that RIZ1 is a specific target of inactivation in human gastric cancer.",

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doi = "10.1038/sj.onc.1206403",

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T1 - Biallelic inactivation of the RIZ1 gene in human gastric cancer

AU - Tokumaru, Yutaka

AU - Nomoto, Shuji

AU - Jerónimo, Carmen

AU - Henrique, Rui

AU - Harden, Susan

AU - Trink, Barry

AU - Sidransky, David

PY - 2003/10/9

Y1 - 2003/10/9

N2 - The distal short arm of chromosome 1 is commonly deleted in a variety of human neoplasms including gastrointestinal cancer. Genetic alterations of the retinoblastoma protein-interacting zing-finger gene (RIZ)1 including loss of heterozygosity (LOH) at 1p36, frameshift mutations, and promoter hypermethylation were reported previously in several cancers. In this study, we evaluated RIZ1 in 30 primary gastric cancers and found frameshift mutations in two cases (6.7%). Moreover, using real-time quantitative methylation-specific PCR, methylation of the RIZ1 promoter was detected in 11 (37%) cases. In all 11 cases with methylation, inactivation of the second allele occurred through frameshift mutation, LOH or promoter methylation. Our results suggest that RIZ1 is a specific target of inactivation in human gastric cancer.

AB - The distal short arm of chromosome 1 is commonly deleted in a variety of human neoplasms including gastrointestinal cancer. Genetic alterations of the retinoblastoma protein-interacting zing-finger gene (RIZ)1 including loss of heterozygosity (LOH) at 1p36, frameshift mutations, and promoter hypermethylation were reported previously in several cancers. In this study, we evaluated RIZ1 in 30 primary gastric cancers and found frameshift mutations in two cases (6.7%). Moreover, using real-time quantitative methylation-specific PCR, methylation of the RIZ1 promoter was detected in 11 (37%) cases. In all 11 cases with methylation, inactivation of the second allele occurred through frameshift mutation, LOH or promoter methylation. Our results suggest that RIZ1 is a specific target of inactivation in human gastric cancer.

KW - Gastric cancer tumor suppressor gene

KW - Gene silencing

KW - Hypermethylation

KW - RIZ1

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DO - 10.1038/sj.onc.1206403

M3 - Article

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AN - SCOPUS:0242406711

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SP - 6954

EP - 6958

JO - Oncogene

JF - Oncogene

IS - 44

ER -

Biallelic inactivation of the RIZ1 gene in human gastric cancer

Abstract

UN SDGs

Keywords

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