@article{bfd612ba87dd487d9c5598c5938a0b2a,
title = "Bi-orientation of achiasmatic chromosomes in meiosis I oocytes contributes to aneuploidy in mice",
abstract = "The spindle assembly checkpoint guards against chromosomal missegregation but does not induce arrest in oocytes that contain a few achiasmatic chromosomes (univalents). We followed the fate of univalents in oocytes during the first meiotic division, and although these preserved a meiotic kinetochore structure, they were also bi-oriented in a mitotic manner. The hybrid chromosomal configuration attained by univalents allows them to evade the spindle assembly checkpoint and contribute to aneuploidy in oocytes.",
author = "Anna Kouznetsova and Lisa Lister and Magnus Nordenskj{\"o}ld and Mary Herbert and Christer H{\"o}{\"o}g",
note = "Funding Information: We are grateful to S. Sahlen for the introduction to the SKY technique, L. Ferguson for the help with the oocyte collection, G. Greggains for the support in data analysis and O. Shupliakov and N. Tomilin for the assistance in the electron microscopy field. This work was supported by grants from the Swedish Cancer Society, the Swedish Research Council, Karolinska Institutet and a grant from Birth Defects Foundation to M.H.",
year = "2007",
month = aug,
doi = "10.1038/ng2065",
language = "English",
volume = "39",
pages = "966--968",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "8",
}