Beyond the Powerhouse: Integrating Mitonuclear Evolution, Physiology, and Theory in Comparative Biology

Justin C. Havird, Ryan J. Weaver, Liliana Milani, Fabrizio Ghiselli, Ryan Greenway, Adam J. Ramsey, Ana G. Jimenez, Damian K. Dowling, Wendy R. Hood, Kristi L. Montooth, Suzanne Estes, Patricia M. Schulte, Inna M. Sokolova, Geoffrey E. Hill

Research output: Contribution to journalReview ArticleOther

5 Citations (Scopus)


Eukaryotes are the outcome of an ancient symbiosis and as such, eukaryotic cells fundamentally possess two genomes. As a consequence, gene products encoded by both nuclear and mitochondrial genomes must interact in an intimate and precise fashion to enable aerobic respiration in eukaryotes. This genomic architecture of eukaryotes is proposed to necessitate perpetual coevolution between the nuclear and mitochondrial genomes to maintain coadaptation, but the presence of two genomes also creates the opportunity for intracellular conflict. In the collection of papers that constitute this symposium volume, scientists working in diverse organismal systems spanning vast biological scales address emerging topics in integrative, comparative biology in light of mitonuclear interactions.

Original languageEnglish
Pages (from-to)856-863
Number of pages8
JournalIntegrative and Comparative Biology
Issue number4
Publication statusPublished - 1 Oct 2019


  • Evolution
  • Mitonuclear

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