Betamethasone for lung maturation: Testing dose and formulation in fetal sheep

Alan Jobe, Timothy Moss, Ilias Nitsos, Machiko Ikegami, Suhas Kallapur, John Newnham

Research output: Contribution to journalArticleResearchpeer-review

Abstract

OBJECTIVE: We evaluated lung maturation responses to the mixture of betamethasone phosphate (Beta-PO4) + betamethasone acetate (Beta-Ac) in comparison to Beta-PO4 or Beta-Ac in fetal sheep. STUDY DESIGN: Ewes carrying singleton pregnancies at 122 days of gestation were randomized to single doses of 0.5 mg/kg Beta-PO4 + Beta-Ac, 0.25 mg/kg Beta-PO4, 0.5 mg/kg Beta-PO4, or 0.25 mg/kg Beta-Ac given 48 hours before delivery. These treatments were compared with saline placebo and 2 doses of 0.5 mg/kg Beta-PO4 + Beta-Ac that were given 48 and 24 hours before delivery. Fetal lung maturation was evaluated. RESULTS: The 2 doses of the Beta-PO4 + Beta-Ac mixture gave the best lung maturation. Single doses of the Beta-PO4 + Beta-Ac mixture and Beta-Ac alone also induced lung maturation. There were no consistent responses to either dose of Beta-PO4. CONCLUSION: Beta-PO4 alone is ineffective with the dosing schedule used; Beta-Ac can induce lung maturation. However, the best responses result from the mixture of Beta-PO4 + Beta-Ac.
Original languageEnglish
Pages (from-to)523.e1 - 523.e6
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Volume197
Issue number5
DOIs
Publication statusPublished - 2007
Externally publishedYes

Cite this

Jobe, Alan ; Moss, Timothy ; Nitsos, Ilias ; Ikegami, Machiko ; Kallapur, Suhas ; Newnham, John. / Betamethasone for lung maturation: Testing dose and formulation in fetal sheep. In: American Journal of Obstetrics and Gynecology. 2007 ; Vol. 197, No. 5. pp. 523.e1 - 523.e6.
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title = "Betamethasone for lung maturation: Testing dose and formulation in fetal sheep",
abstract = "OBJECTIVE: We evaluated lung maturation responses to the mixture of betamethasone phosphate (Beta-PO4) + betamethasone acetate (Beta-Ac) in comparison to Beta-PO4 or Beta-Ac in fetal sheep. STUDY DESIGN: Ewes carrying singleton pregnancies at 122 days of gestation were randomized to single doses of 0.5 mg/kg Beta-PO4 + Beta-Ac, 0.25 mg/kg Beta-PO4, 0.5 mg/kg Beta-PO4, or 0.25 mg/kg Beta-Ac given 48 hours before delivery. These treatments were compared with saline placebo and 2 doses of 0.5 mg/kg Beta-PO4 + Beta-Ac that were given 48 and 24 hours before delivery. Fetal lung maturation was evaluated. RESULTS: The 2 doses of the Beta-PO4 + Beta-Ac mixture gave the best lung maturation. Single doses of the Beta-PO4 + Beta-Ac mixture and Beta-Ac alone also induced lung maturation. There were no consistent responses to either dose of Beta-PO4. CONCLUSION: Beta-PO4 alone is ineffective with the dosing schedule used; Beta-Ac can induce lung maturation. However, the best responses result from the mixture of Beta-PO4 + Beta-Ac.",
author = "Alan Jobe and Timothy Moss and Ilias Nitsos and Machiko Ikegami and Suhas Kallapur and John Newnham",
year = "2007",
doi = "10.1016/j.ajog.2007.04.004",
language = "English",
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pages = "523.e1 -- 523.e6",
journal = "American Journal of Obstetrics and Gynecology",
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Betamethasone for lung maturation: Testing dose and formulation in fetal sheep. / Jobe, Alan; Moss, Timothy; Nitsos, Ilias; Ikegami, Machiko; Kallapur, Suhas; Newnham, John.

In: American Journal of Obstetrics and Gynecology, Vol. 197, No. 5, 2007, p. 523.e1 - 523.e6.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Betamethasone for lung maturation: Testing dose and formulation in fetal sheep

AU - Jobe, Alan

AU - Moss, Timothy

AU - Nitsos, Ilias

AU - Ikegami, Machiko

AU - Kallapur, Suhas

AU - Newnham, John

PY - 2007

Y1 - 2007

N2 - OBJECTIVE: We evaluated lung maturation responses to the mixture of betamethasone phosphate (Beta-PO4) + betamethasone acetate (Beta-Ac) in comparison to Beta-PO4 or Beta-Ac in fetal sheep. STUDY DESIGN: Ewes carrying singleton pregnancies at 122 days of gestation were randomized to single doses of 0.5 mg/kg Beta-PO4 + Beta-Ac, 0.25 mg/kg Beta-PO4, 0.5 mg/kg Beta-PO4, or 0.25 mg/kg Beta-Ac given 48 hours before delivery. These treatments were compared with saline placebo and 2 doses of 0.5 mg/kg Beta-PO4 + Beta-Ac that were given 48 and 24 hours before delivery. Fetal lung maturation was evaluated. RESULTS: The 2 doses of the Beta-PO4 + Beta-Ac mixture gave the best lung maturation. Single doses of the Beta-PO4 + Beta-Ac mixture and Beta-Ac alone also induced lung maturation. There were no consistent responses to either dose of Beta-PO4. CONCLUSION: Beta-PO4 alone is ineffective with the dosing schedule used; Beta-Ac can induce lung maturation. However, the best responses result from the mixture of Beta-PO4 + Beta-Ac.

AB - OBJECTIVE: We evaluated lung maturation responses to the mixture of betamethasone phosphate (Beta-PO4) + betamethasone acetate (Beta-Ac) in comparison to Beta-PO4 or Beta-Ac in fetal sheep. STUDY DESIGN: Ewes carrying singleton pregnancies at 122 days of gestation were randomized to single doses of 0.5 mg/kg Beta-PO4 + Beta-Ac, 0.25 mg/kg Beta-PO4, 0.5 mg/kg Beta-PO4, or 0.25 mg/kg Beta-Ac given 48 hours before delivery. These treatments were compared with saline placebo and 2 doses of 0.5 mg/kg Beta-PO4 + Beta-Ac that were given 48 and 24 hours before delivery. Fetal lung maturation was evaluated. RESULTS: The 2 doses of the Beta-PO4 + Beta-Ac mixture gave the best lung maturation. Single doses of the Beta-PO4 + Beta-Ac mixture and Beta-Ac alone also induced lung maturation. There were no consistent responses to either dose of Beta-PO4. CONCLUSION: Beta-PO4 alone is ineffective with the dosing schedule used; Beta-Ac can induce lung maturation. However, the best responses result from the mixture of Beta-PO4 + Beta-Ac.

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