TY - JOUR
T1 - Betalain- and betacyanin-rich supplements’ impacts on the PBMC SIRT1 and LOX1 genes expression and Sirtuin-1 protein levels in coronary artery disease patients
T2 - A pilot crossover clinical trial
AU - Rahimi, Parisa
AU - Mesbah-Namin, Seyed Alireza
AU - Ostadrahimi, Alireza
AU - Separham, Ahmad
AU - Asghari Jafarabadi, Mohammad
N1 - Funding Information:
This PhD-research project was supported by the Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Also, we cordially thank the director and all colleagues of the Nutrition Research Centre, Faculty of Nutrition, Tabriz University of Medical Sciences for their support and collaboration. All authors declare no conflict of interest. The experiments comply with the current laws of Iran.
Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/9
Y1 - 2019/9
N2 - Activation of Sirtuin-1 (SIRT1) is a considered candidate for the prevention of cardiovascular diseases. SIRT1 as a longevity factor regulates human cell lifespan and influences aspects of age-dependent atherosclerosis. Betalains can significantly increase the lifespan of Caenorhabditis elegans. This effect may be agreeable with activation of SIRT1. Thus, this study investigates the effects of betalains on SIRT1 and Lectin-like Oxidized LDL Receptor 1 (LOX1) expression in coronary artery disease patients. Participants received three treatments (a betalains-rich supplement of red beetroot, a betacyanins-rich supplement of Opuntia stricta and a placebo; daily for two weeks) on three occasions which separated by washout periods. A notable elevation in SIRT1 levels and a considerable decrease in the expression levels of LOX1 and plasma concentration of high sensitive C Reactive Protein (hs-CRP) were observed after both supplementations. In conclusion, it appears that betalains could be considered as the new candidates in studies about age-related diseases.
AB - Activation of Sirtuin-1 (SIRT1) is a considered candidate for the prevention of cardiovascular diseases. SIRT1 as a longevity factor regulates human cell lifespan and influences aspects of age-dependent atherosclerosis. Betalains can significantly increase the lifespan of Caenorhabditis elegans. This effect may be agreeable with activation of SIRT1. Thus, this study investigates the effects of betalains on SIRT1 and Lectin-like Oxidized LDL Receptor 1 (LOX1) expression in coronary artery disease patients. Participants received three treatments (a betalains-rich supplement of red beetroot, a betacyanins-rich supplement of Opuntia stricta and a placebo; daily for two weeks) on three occasions which separated by washout periods. A notable elevation in SIRT1 levels and a considerable decrease in the expression levels of LOX1 and plasma concentration of high sensitive C Reactive Protein (hs-CRP) were observed after both supplementations. In conclusion, it appears that betalains could be considered as the new candidates in studies about age-related diseases.
KW - Age-related diseases
KW - Atherosclerosis
KW - Opuntia stricta
KW - Prickly Pear
KW - Red Beetroot
KW - Sirtuin
UR - https://www.scopus.com/pages/publications/85067825099
U2 - 10.1016/j.jff.2019.06.003
DO - 10.1016/j.jff.2019.06.003
M3 - Article
AN - SCOPUS:85067825099
SN - 1756-4646
VL - 60
JO - Journal of Functional Foods
JF - Journal of Functional Foods
M1 - 103401
ER -
SDG 3 Good Health and Well-being