Beta-Blocker dialyzability and mortality in older patients receiving hemodialysis

Matthew A Weir; Stephanie N Dixon; Jamie L Fleet; Matthew Allan Roberts; Daniel G Hackam; Matthew J Oliver; Rita S Suri; Robert R Quinn; Sundus Ozair; Michael Beyea; Abhijat Kitchlu; Amit X Garg

doi:10.1681/ASN.2014040324

Beta-Blocker dialyzability and mortality in older patients receiving hemodialysis

Matthew A Weir, Stephanie N Dixon, Jamie L Fleet, Matthew Allan Roberts, Daniel G Hackam, Matthew J Oliver, Rita S Suri, Robert R Quinn, Sundus Ozair, Michael Beyea, Abhijat Kitchlu, Amit X Garg

Eastern Health Clinical School

Research output: Contribution to journal › Article › Research › peer-review

97 Citations (Scopus)

Abstract

Some beta-blockers are efficiently removed from the circulation by hemodialysis ( high dialyzability ) whereas others are not ( low dialyzability ). This characteristic may influence the effectiveness of the ?-blockers among patients receiving long-term hemodialysis. To determine whether new use of a high-dialyzability ?-blocker compared with a low-dialyzability ?-blocker associates with a higher rate of mortality in patients older than age 66 years receiving long-term hemodialysis, we conducted a propensity-matched population-based retrospective cohort study using the linked healthcare databases of Ontario, Canada. The high-dialyzability group (n=3294) included patients initiating atenolol, acebutolol, or metoprolol. The low-dialyzability group (n=3294) included patients initiating bisoprolol or propranolol. Initiation of a high-versus low-dialyzability ?-blocker was associated with a higher risk of death in the following 180 days (relative risk, 1.4; 95 confidence interval, 1.1 to 1.8; P

Original language	English
Pages (from-to)	987 - 996
Number of pages	10
Journal	Journal of the American Society of Nephrology
Volume	26
Issue number	4
DOIs	https://doi.org/10.1681/ASN.2014040324
Publication status	Published - 2015

Access to Document

10.1681/ASN.2014040324

Cite this

@article{5a559a9f887a476eba50b66c9789d752,

title = "Beta-Blocker dialyzability and mortality in older patients receiving hemodialysis",

abstract = "Some beta-blockers are efficiently removed from the circulation by hemodialysis ( high dialyzability ) whereas others are not ( low dialyzability ). This characteristic may influence the effectiveness of the ?-blockers among patients receiving long-term hemodialysis. To determine whether new use of a high-dialyzability ?-blocker compared with a low-dialyzability ?-blocker associates with a higher rate of mortality in patients older than age 66 years receiving long-term hemodialysis, we conducted a propensity-matched population-based retrospective cohort study using the linked healthcare databases of Ontario, Canada. The high-dialyzability group (n=3294) included patients initiating atenolol, acebutolol, or metoprolol. The low-dialyzability group (n=3294) included patients initiating bisoprolol or propranolol. Initiation of a high-versus low-dialyzability ?-blocker was associated with a higher risk of death in the following 180 days (relative risk, 1.4; 95 confidence interval, 1.1 to 1.8; P",

author = "Weir, {Matthew A} and Dixon, {Stephanie N} and Fleet, {Jamie L} and Roberts, {Matthew Allan} and Hackam, {Daniel G} and Oliver, {Matthew J} and Suri, {Rita S} and Quinn, {Robert R} and Sundus Ozair and Michael Beyea and Abhijat Kitchlu and Garg, {Amit X}",

year = "2015",

doi = "10.1681/ASN.2014040324",

language = "English",

volume = "26",

pages = "987 -- 996",

journal = "Journal of the American Society of Nephrology",

issn = "1046-6673",

publisher = "American Society of Nephrology",

number = "4",

}

TY - JOUR

T1 - Beta-Blocker dialyzability and mortality in older patients receiving hemodialysis

AU - Weir, Matthew A

AU - Dixon, Stephanie N

AU - Fleet, Jamie L

AU - Roberts, Matthew Allan

AU - Hackam, Daniel G

AU - Oliver, Matthew J

AU - Suri, Rita S

AU - Quinn, Robert R

AU - Ozair, Sundus

AU - Beyea, Michael

AU - Kitchlu, Abhijat

AU - Garg, Amit X

PY - 2015

Y1 - 2015

N2 - Some beta-blockers are efficiently removed from the circulation by hemodialysis ( high dialyzability ) whereas others are not ( low dialyzability ). This characteristic may influence the effectiveness of the ?-blockers among patients receiving long-term hemodialysis. To determine whether new use of a high-dialyzability ?-blocker compared with a low-dialyzability ?-blocker associates with a higher rate of mortality in patients older than age 66 years receiving long-term hemodialysis, we conducted a propensity-matched population-based retrospective cohort study using the linked healthcare databases of Ontario, Canada. The high-dialyzability group (n=3294) included patients initiating atenolol, acebutolol, or metoprolol. The low-dialyzability group (n=3294) included patients initiating bisoprolol or propranolol. Initiation of a high-versus low-dialyzability ?-blocker was associated with a higher risk of death in the following 180 days (relative risk, 1.4; 95 confidence interval, 1.1 to 1.8; P

AB - Some beta-blockers are efficiently removed from the circulation by hemodialysis ( high dialyzability ) whereas others are not ( low dialyzability ). This characteristic may influence the effectiveness of the ?-blockers among patients receiving long-term hemodialysis. To determine whether new use of a high-dialyzability ?-blocker compared with a low-dialyzability ?-blocker associates with a higher rate of mortality in patients older than age 66 years receiving long-term hemodialysis, we conducted a propensity-matched population-based retrospective cohort study using the linked healthcare databases of Ontario, Canada. The high-dialyzability group (n=3294) included patients initiating atenolol, acebutolol, or metoprolol. The low-dialyzability group (n=3294) included patients initiating bisoprolol or propranolol. Initiation of a high-versus low-dialyzability ?-blocker was associated with a higher risk of death in the following 180 days (relative risk, 1.4; 95 confidence interval, 1.1 to 1.8; P

UR - http://jasn.asnjournals.org/content/26/4/987.full.pdf+html

U2 - 10.1681/ASN.2014040324

DO - 10.1681/ASN.2014040324

M3 - Article

SN - 1046-6673

VL - 26

SP - 987

EP - 996

JO - Journal of the American Society of Nephrology

JF - Journal of the American Society of Nephrology

IS - 4

ER -

Beta-Blocker dialyzability and mortality in older patients receiving hemodialysis

Abstract

Access to Document

Other files and links

Cite this