Bestatin induces specific changes in Trypanosoma cruzi dipeptide pool

Andrea Trochine; Darren J. Creek; Paula Faral-Tello; Michael P. Barrett; Carlos Robello

doi:10.1128/AAC.05046-14

Bestatin induces specific changes in Trypanosoma cruzi dipeptide pool

Andrea Trochine, Darren J. Creek, Paula Faral-Tello, Michael P. Barrett, Carlos Robello

Drug Delivery Disposition & Dynamics

Research output: Contribution to journal › Article › Research › peer-review

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Abstract

Proteases and peptidases in Trypanosoma cruzi are considered potential targets for antichagasic chemotherapy. We monitored changes in low-mass metabolites in T. cruzi epimastigotes treated with bestatin, a dipeptide metalloaminopeptidase inhibitor. After treatment, multiple dipeptides were shown to be increased, confirming in situ inhibition of the leucine aminopeptidase of T. cruzi (LAPTc) and probably other peptidases.

Original language	English
Pages (from-to)	2921-2925
Number of pages	5
Journal	Antimicrobial Agents and Chemotherapy
Volume	59
Issue number	5
DOIs	https://doi.org/10.1128/AAC.05046-14
Publication status	Published - 1 May 2015

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Cite this

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title = "Bestatin induces specific changes in Trypanosoma cruzi dipeptide pool",

abstract = "Proteases and peptidases in Trypanosoma cruzi are considered potential targets for antichagasic chemotherapy. We monitored changes in low-mass metabolites in T. cruzi epimastigotes treated with bestatin, a dipeptide metalloaminopeptidase inhibitor. After treatment, multiple dipeptides were shown to be increased, confirming in situ inhibition of the leucine aminopeptidase of T. cruzi (LAPTc) and probably other peptidases.",

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AU - Trochine, Andrea

AU - Creek, Darren J.

AU - Faral-Tello, Paula

AU - Barrett, Michael P.

AU - Robello, Carlos

PY - 2015/5/1

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AB - Proteases and peptidases in Trypanosoma cruzi are considered potential targets for antichagasic chemotherapy. We monitored changes in low-mass metabolites in T. cruzi epimastigotes treated with bestatin, a dipeptide metalloaminopeptidase inhibitor. After treatment, multiple dipeptides were shown to be increased, confirming in situ inhibition of the leucine aminopeptidase of T. cruzi (LAPTc) and probably other peptidases.

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DO - 10.1128/AAC.05046-14

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SN - 1098-6596

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JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 5

ER -

Bestatin induces specific changes in Trypanosoma cruzi dipeptide pool

Abstract

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