Bestatin induces specific changes in Trypanosoma cruzi dipeptide pool

Andrea Trochine; Darren J. Creek; Paula Faral-Tello; Michael P. Barrett; Carlos Robello

doi:10.1128/AAC.05046-14

Bestatin induces specific changes in Trypanosoma cruzi dipeptide pool

Andrea Trochine, Darren J. Creek, Paula Faral-Tello, Michael P. Barrett, Carlos Robello

Drug Delivery Disposition & Dynamics

Research output: Contribution to journal › Article › Research › peer-review

9 Citations (Scopus)

Abstract

Proteases and peptidases in Trypanosoma cruzi are considered potential targets for antichagasic chemotherapy. We monitored changes in low-mass metabolites in T. cruzi epimastigotes treated with bestatin, a dipeptide metalloaminopeptidase inhibitor. After treatment, multiple dipeptides were shown to be increased, confirming in situ inhibition of the leucine aminopeptidase of T. cruzi (LAPTc) and probably other peptidases.

Original language	English
Pages (from-to)	2921-2925
Number of pages	5
Journal	Antimicrobial Agents and Chemotherapy
Volume	59
Issue number	5
DOIs	https://doi.org/10.1128/AAC.05046-14
Publication status	Published - 1 May 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1128/AAC.05046-14

3486127-oaFinal published version, 781 KB

Cite this

@article{ff46364a669a4649b389013f850c6375,

title = "Bestatin induces specific changes in Trypanosoma cruzi dipeptide pool",

abstract = "Proteases and peptidases in Trypanosoma cruzi are considered potential targets for antichagasic chemotherapy. We monitored changes in low-mass metabolites in T. cruzi epimastigotes treated with bestatin, a dipeptide metalloaminopeptidase inhibitor. After treatment, multiple dipeptides were shown to be increased, confirming in situ inhibition of the leucine aminopeptidase of T. cruzi (LAPTc) and probably other peptidases.",

author = "Andrea Trochine and Creek, {Darren J.} and Paula Faral-Tello and Barrett, {Michael P.} and Carlos Robello",

year = "2015",

month = may,

day = "1",

doi = "10.1128/AAC.05046-14",

language = "English",

volume = "59",

pages = "2921--2925",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "1098-6596",

publisher = "American Society for Microbiology",

number = "5",

}

TY - JOUR

T1 - Bestatin induces specific changes in Trypanosoma cruzi dipeptide pool

AU - Trochine, Andrea

AU - Creek, Darren J.

AU - Faral-Tello, Paula

AU - Barrett, Michael P.

AU - Robello, Carlos

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Proteases and peptidases in Trypanosoma cruzi are considered potential targets for antichagasic chemotherapy. We monitored changes in low-mass metabolites in T. cruzi epimastigotes treated with bestatin, a dipeptide metalloaminopeptidase inhibitor. After treatment, multiple dipeptides were shown to be increased, confirming in situ inhibition of the leucine aminopeptidase of T. cruzi (LAPTc) and probably other peptidases.

AB - Proteases and peptidases in Trypanosoma cruzi are considered potential targets for antichagasic chemotherapy. We monitored changes in low-mass metabolites in T. cruzi epimastigotes treated with bestatin, a dipeptide metalloaminopeptidase inhibitor. After treatment, multiple dipeptides were shown to be increased, confirming in situ inhibition of the leucine aminopeptidase of T. cruzi (LAPTc) and probably other peptidases.

UR - http://www.scopus.com/inward/record.url?scp=84931291777&partnerID=8YFLogxK

U2 - 10.1128/AAC.05046-14

DO - 10.1128/AAC.05046-14

M3 - Article

C2 - 25712359

SN - 1098-6596

VL - 59

SP - 2921

EP - 2925

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 5

ER -

Bestatin induces specific changes in Trypanosoma cruzi dipeptide pool

Abstract

UN SDGs

Access to Document

Other files and links

Cite this