Bestatin induces specific changes in Trypanosoma cruzi dipeptide pool

Andrea Trochine, Darren J. Creek, Paula Faral-Tello, Michael P. Barrett, Carlos Robello

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Abstract

Proteases and peptidases in Trypanosoma cruzi are considered potential targets for antichagasic chemotherapy. We monitored changes in low-mass metabolites in T. cruzi epimastigotes treated with bestatin, a dipeptide metalloaminopeptidase inhibitor. After treatment, multiple dipeptides were shown to be increased, confirming in situ inhibition of the leucine aminopeptidase of T. cruzi (LAPTc) and probably other peptidases.

Original languageEnglish
Pages (from-to)2921-2925
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume59
Issue number5
DOIs
Publication statusPublished - 1 May 2015

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