Benefits for Type 2 Diabetes of Interrupting Prolonged Sitting With Brief Bouts of Light Walking or Simple Resistance Activities

Paddy C. Dempsey, Robyn N. Larsen, Parneet Sethi, Julian W. Sacre, Nora E. Straznicky, Neale D. Cohen, Ester Cerin, Gavin W. Lambert, Neville Owen, Bronwyn A. Kingwell, David W. Dunstan

Research output: Contribution to journalArticleResearchpeer-review

Abstract

OBJECTIVE To determine whether interrupting prolonged sitting with brief bouts of lightintensity walking (LW) or simple resistance activities (SRA) improves postprandial cardiometabolic risk markers in adults with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS In a randomized crossover trial, 24 inactive overweight/obese adults with T2D (14 men 62 6 6 years old) underwent the following 8-h conditions on three separate days (with 6-14 days washout): uninterrupted sitting (control) (SIT), sitting plus 3-min bouts of LW (3.2 km. h21) every 30 min, and sitting plus 3-min bouts of SRA (half-squats, calf raises, gluteal contractions, and knee raises) every 30 min. Standardized meals were consumed during each condition. Incremental areas under the curve (iAUCs) for glucose, insulin, C-peptide, and triglycerides were compared between conditions. RESULTS Compared with SIT, both activity-break conditions significantly attenuated iAUCs for glucose (SIT mean 24.2 mmol . h . L21 [95% CI 20.4-28.0] vs. LW 14.8 [11.0- 18.6] and SRA 14.7 [10.9-18.5]), insulin (SIT 3,293 pmol . h . L21 [2,887-3,700] vs. LW 2,104 [1,696-2,511] and SRA 2,066 [1,660-2,473]), and C-peptide (SIT 15,641 pmol . h . L21 [14,353-16,929] vs. LW 11,504 [10,209-12,799] and SRA 11,012 [9,723-12,301]) (all P < 0.001). The iAUC for triglycerides was significantly attenuated for SRA (P < 0.001) but not for LW(SIT 4.8mmol . h . L21 [3.6-6.0] vs. LW4.0 [2.8-5.1] and SRA 2.9 [1.7-4.1]). CONCLUSIONS Interrupting prolonged sitting with brief bouts of LW or SRA attenuates acute postprandial glucose, insulin, C-peptide, and triglyceride responses in adults with T2D. With poor adherence to structured exercise, this approach is potentially beneficial and practical.

Original languageEnglish
Pages (from-to)964-972
Number of pages9
JournalDiabetes Care
Volume39
Issue number6
DOIs
Publication statusPublished - 1 Jun 2016

Cite this

@article{0c17ff1669df485caa0f7985845fc666,
title = "Benefits for Type 2 Diabetes of Interrupting Prolonged Sitting With Brief Bouts of Light Walking or Simple Resistance Activities",
abstract = "OBJECTIVE To determine whether interrupting prolonged sitting with brief bouts of lightintensity walking (LW) or simple resistance activities (SRA) improves postprandial cardiometabolic risk markers in adults with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS In a randomized crossover trial, 24 inactive overweight/obese adults with T2D (14 men 62 6 6 years old) underwent the following 8-h conditions on three separate days (with 6-14 days washout): uninterrupted sitting (control) (SIT), sitting plus 3-min bouts of LW (3.2 km. h21) every 30 min, and sitting plus 3-min bouts of SRA (half-squats, calf raises, gluteal contractions, and knee raises) every 30 min. Standardized meals were consumed during each condition. Incremental areas under the curve (iAUCs) for glucose, insulin, C-peptide, and triglycerides were compared between conditions. RESULTS Compared with SIT, both activity-break conditions significantly attenuated iAUCs for glucose (SIT mean 24.2 mmol . h . L21 [95{\%} CI 20.4-28.0] vs. LW 14.8 [11.0- 18.6] and SRA 14.7 [10.9-18.5]), insulin (SIT 3,293 pmol . h . L21 [2,887-3,700] vs. LW 2,104 [1,696-2,511] and SRA 2,066 [1,660-2,473]), and C-peptide (SIT 15,641 pmol . h . L21 [14,353-16,929] vs. LW 11,504 [10,209-12,799] and SRA 11,012 [9,723-12,301]) (all P < 0.001). The iAUC for triglycerides was significantly attenuated for SRA (P < 0.001) but not for LW(SIT 4.8mmol . h . L21 [3.6-6.0] vs. LW4.0 [2.8-5.1] and SRA 2.9 [1.7-4.1]). CONCLUSIONS Interrupting prolonged sitting with brief bouts of LW or SRA attenuates acute postprandial glucose, insulin, C-peptide, and triglyceride responses in adults with T2D. With poor adherence to structured exercise, this approach is potentially beneficial and practical.",
author = "Dempsey, {Paddy C.} and Larsen, {Robyn N.} and Parneet Sethi and Sacre, {Julian W.} and Straznicky, {Nora E.} and Cohen, {Neale D.} and Ester Cerin and Lambert, {Gavin W.} and Neville Owen and Kingwell, {Bronwyn A.} and Dunstan, {David W.}",
year = "2016",
month = "6",
day = "1",
doi = "10.2337/dc15-2336",
language = "English",
volume = "39",
pages = "964--972",
journal = "Diabetes Care",
issn = "0149-5992",
publisher = "Am Diabetes Assoc",
number = "6",

}

Benefits for Type 2 Diabetes of Interrupting Prolonged Sitting With Brief Bouts of Light Walking or Simple Resistance Activities. / Dempsey, Paddy C.; Larsen, Robyn N.; Sethi, Parneet; Sacre, Julian W.; Straznicky, Nora E.; Cohen, Neale D.; Cerin, Ester; Lambert, Gavin W.; Owen, Neville; Kingwell, Bronwyn A.; Dunstan, David W.

In: Diabetes Care, Vol. 39, No. 6, 01.06.2016, p. 964-972.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Benefits for Type 2 Diabetes of Interrupting Prolonged Sitting With Brief Bouts of Light Walking or Simple Resistance Activities

AU - Dempsey, Paddy C.

AU - Larsen, Robyn N.

AU - Sethi, Parneet

AU - Sacre, Julian W.

AU - Straznicky, Nora E.

AU - Cohen, Neale D.

AU - Cerin, Ester

AU - Lambert, Gavin W.

AU - Owen, Neville

AU - Kingwell, Bronwyn A.

AU - Dunstan, David W.

PY - 2016/6/1

Y1 - 2016/6/1

N2 - OBJECTIVE To determine whether interrupting prolonged sitting with brief bouts of lightintensity walking (LW) or simple resistance activities (SRA) improves postprandial cardiometabolic risk markers in adults with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS In a randomized crossover trial, 24 inactive overweight/obese adults with T2D (14 men 62 6 6 years old) underwent the following 8-h conditions on three separate days (with 6-14 days washout): uninterrupted sitting (control) (SIT), sitting plus 3-min bouts of LW (3.2 km. h21) every 30 min, and sitting plus 3-min bouts of SRA (half-squats, calf raises, gluteal contractions, and knee raises) every 30 min. Standardized meals were consumed during each condition. Incremental areas under the curve (iAUCs) for glucose, insulin, C-peptide, and triglycerides were compared between conditions. RESULTS Compared with SIT, both activity-break conditions significantly attenuated iAUCs for glucose (SIT mean 24.2 mmol . h . L21 [95% CI 20.4-28.0] vs. LW 14.8 [11.0- 18.6] and SRA 14.7 [10.9-18.5]), insulin (SIT 3,293 pmol . h . L21 [2,887-3,700] vs. LW 2,104 [1,696-2,511] and SRA 2,066 [1,660-2,473]), and C-peptide (SIT 15,641 pmol . h . L21 [14,353-16,929] vs. LW 11,504 [10,209-12,799] and SRA 11,012 [9,723-12,301]) (all P < 0.001). The iAUC for triglycerides was significantly attenuated for SRA (P < 0.001) but not for LW(SIT 4.8mmol . h . L21 [3.6-6.0] vs. LW4.0 [2.8-5.1] and SRA 2.9 [1.7-4.1]). CONCLUSIONS Interrupting prolonged sitting with brief bouts of LW or SRA attenuates acute postprandial glucose, insulin, C-peptide, and triglyceride responses in adults with T2D. With poor adherence to structured exercise, this approach is potentially beneficial and practical.

AB - OBJECTIVE To determine whether interrupting prolonged sitting with brief bouts of lightintensity walking (LW) or simple resistance activities (SRA) improves postprandial cardiometabolic risk markers in adults with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS In a randomized crossover trial, 24 inactive overweight/obese adults with T2D (14 men 62 6 6 years old) underwent the following 8-h conditions on three separate days (with 6-14 days washout): uninterrupted sitting (control) (SIT), sitting plus 3-min bouts of LW (3.2 km. h21) every 30 min, and sitting plus 3-min bouts of SRA (half-squats, calf raises, gluteal contractions, and knee raises) every 30 min. Standardized meals were consumed during each condition. Incremental areas under the curve (iAUCs) for glucose, insulin, C-peptide, and triglycerides were compared between conditions. RESULTS Compared with SIT, both activity-break conditions significantly attenuated iAUCs for glucose (SIT mean 24.2 mmol . h . L21 [95% CI 20.4-28.0] vs. LW 14.8 [11.0- 18.6] and SRA 14.7 [10.9-18.5]), insulin (SIT 3,293 pmol . h . L21 [2,887-3,700] vs. LW 2,104 [1,696-2,511] and SRA 2,066 [1,660-2,473]), and C-peptide (SIT 15,641 pmol . h . L21 [14,353-16,929] vs. LW 11,504 [10,209-12,799] and SRA 11,012 [9,723-12,301]) (all P < 0.001). The iAUC for triglycerides was significantly attenuated for SRA (P < 0.001) but not for LW(SIT 4.8mmol . h . L21 [3.6-6.0] vs. LW4.0 [2.8-5.1] and SRA 2.9 [1.7-4.1]). CONCLUSIONS Interrupting prolonged sitting with brief bouts of LW or SRA attenuates acute postprandial glucose, insulin, C-peptide, and triglyceride responses in adults with T2D. With poor adherence to structured exercise, this approach is potentially beneficial and practical.

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U2 - 10.2337/dc15-2336

DO - 10.2337/dc15-2336

M3 - Article

VL - 39

SP - 964

EP - 972

JO - Diabetes Care

JF - Diabetes Care

SN - 0149-5992

IS - 6

ER -