Beneficial roles of honey polyphenols against some human degenerative diseases: A review

Md Sakib Hossen, Md Yousuf Ali, M. H.A. Jahurul, Mohamed M. Abdel-Daim, Siew Hua Gan, Md Ibrahim Khalil

Research output: Contribution to journalReview ArticleOtherpeer-review

63 Citations (Scopus)

Abstract

Honey contains many active constituents and antioxidants such as polyphenols. Polyphenols are phytochemicals, a generic term for the several thousand plant-based molecules with antioxidant properties. Many in vitro studies in human cell cultures as well as many animal studies confirm the protective effect of polyphenols on a number of diseases such as cardiovascular diseases (CVD), diabetes, cancer, neurodegenerative diseases, pulmonary diseases, liver diseases and so on. Nevertheless, it is challenging to identify the specific biological mechanism underlying individual polyphenols and to determine how polyphenols impact human health. To date, several studies have attempted to elucidate the molecular pathway for specific polyphenols acting against particular diseases. In this review, we report on the various polyphenols present in different types of honey according to their classification, source, and specific functions and discuss several of the honey polyphenols with the most therapeutic potential to exert an effect on the various pathologies of some major diseases including CVD, diabetes, cancer, and neurodegenerative diseases.

Original languageEnglish
Pages (from-to)1194-1205
Number of pages12
JournalPharmacological Reports
Volume69
Issue number6
DOIs
Publication statusPublished - Dec 2017
Externally publishedYes

Keywords

  • Antioxidants
  • Cancer
  • CVD
  • Diabetes
  • Honey
  • Neurodegenerative disease
  • Polyphenols

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