Behavioural effect of adrenalectomy: Reversal by glucocorticoids or [D-ALA2, MET5]enkephalinamide

Don Jefferys, David Copolov, Dan Irby, John Funder

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Rats adrenalectomized 4-6 d before a 15-min swimming test showed levels of immobility indistinguishable from controls. Retested 24 h later, adrenalectomized rats showed significantly reduced (28%) immobility compared with controls (70%) or hypophysectomized rats (60%), but not hypophysectomized-adrenalectomized rats (41%). The effect of adrenalectomy was reversed by the administration (within 1 h of initial test, but not sebsequently) of dexamethasone (6-20 μg; 65% immobility) and corticosterone (6 mg; 74%), but not by the mineralocorticoid deoxycorticosterone (6 mg; 33%). [D-Ala2, Met5]enkephalinamide (5-50 μg) also restored immobility (66%). We postulate that hormones from both adrenal medulla and cortex are involved in the retention of information post-stress, and that these hormones act directly on the CNS rather than via the pituitary, since the response to adrenalectomy is not dependent on the presence of the pituitary gland.

Original languageEnglish
Pages (from-to)99-103
Number of pages5
JournalEuropean Journal of Pharmacology
Issue number1-2
Publication statusPublished - 19 Aug 1983

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