Pre-aggregated non-amyloid component of alpha-synuclein, NAC(61-95), was injected bilaterally into the CA3 area of rat hippocampus and behaviour was assessed using an alternating-lever cyclic-ratio (ALCR) schedule of operant responding. Four groups of rats were used (n=6 per group), subgroups were treated orally with either ibuprofen (40mg/kg) or vehicle (10 sucrose) twice daily. Intrahippocampal injection of NAC(61-95) increased lever switching errors and numbers of activated astrocytes, and ibuprofen treatment alleviated these effects.
O'Hare, E., Elliott, J. J., Hobson, P., Spanswick, D. C., & Kim, E-M. (2010). Behavioural deterioration induced by intrahippocampal NAC61-95 injections and attenuation with ibuprofen. Behavioural Brain Research, 208(1), 274 - 277. https://doi.org/10.1016/j.bbr.2009.11.027