Behavioural deterioration induced by intrahippocampal NAC61-95 injections and attenuation with ibuprofen

Eugene O'Hare, Jennifer J Elliott, Peter Hobson, David C Spanswick, Eun-Mee Kim

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5 Citations (Scopus)


Pre-aggregated non-amyloid component of alpha-synuclein, NAC(61-95), was injected bilaterally into the CA3 area of rat hippocampus and behaviour was assessed using an alternating-lever cyclic-ratio (ALCR) schedule of operant responding. Four groups of rats were used (n=6 per group), subgroups were treated orally with either ibuprofen (40mg/kg) or vehicle (10 sucrose) twice daily. Intrahippocampal injection of NAC(61-95) increased lever switching errors and numbers of activated astrocytes, and ibuprofen treatment alleviated these effects.
Original languageEnglish
Pages (from-to)274 - 277
Number of pages4
JournalBehavioural Brain Research
Issue number1
Publication statusPublished - 2010
Externally publishedYes

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