Behavioural deterioration induced by intrahippocampal NAC61-95 injections and attenuation with ibuprofen

Eugene O'Hare; Jennifer J Elliott; Peter Hobson; David C Spanswick; Eun-Mee Kim

doi:10.1016/j.bbr.2009.11.027

Behavioural deterioration induced by intrahippocampal NAC61-95 injections and attenuation with ibuprofen

Eugene O'Hare, Jennifer J Elliott, Peter Hobson, David C Spanswick, Eun-Mee Kim

Research output: Contribution to journal › Article › Research › peer-review

5 Citations (Scopus)

Abstract

Pre-aggregated non-amyloid component of alpha-synuclein, NAC(61-95), was injected bilaterally into the CA3 area of rat hippocampus and behaviour was assessed using an alternating-lever cyclic-ratio (ALCR) schedule of operant responding. Four groups of rats were used (n=6 per group), subgroups were treated orally with either ibuprofen (40mg/kg) or vehicle (10 sucrose) twice daily. Intrahippocampal injection of NAC(61-95) increased lever switching errors and numbers of activated astrocytes, and ibuprofen treatment alleviated these effects.

Original language	English
Pages (from-to)	274 - 277
Number of pages	4
Journal	Behavioural Brain Research
Volume	208
Issue number	1
DOIs	https://doi.org/10.1016/j.bbr.2009.11.027
Publication status	Published - 2010
Externally published	Yes

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10.1016/j.bbr.2009.11.027

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title = "Behavioural deterioration induced by intrahippocampal NAC61-95 injections and attenuation with ibuprofen",

abstract = "Pre-aggregated non-amyloid component of alpha-synuclein, NAC(61-95), was injected bilaterally into the CA3 area of rat hippocampus and behaviour was assessed using an alternating-lever cyclic-ratio (ALCR) schedule of operant responding. Four groups of rats were used (n=6 per group), subgroups were treated orally with either ibuprofen (40mg/kg) or vehicle (10 sucrose) twice daily. Intrahippocampal injection of NAC(61-95) increased lever switching errors and numbers of activated astrocytes, and ibuprofen treatment alleviated these effects.",

author = "Eugene O'Hare and Elliott, {Jennifer J} and Peter Hobson and Spanswick, {David C} and Eun-Mee Kim",

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language = "English",

volume = "208",

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AU - O'Hare, Eugene

AU - Elliott, Jennifer J

AU - Hobson, Peter

AU - Spanswick, David C

AU - Kim, Eun-Mee

PY - 2010

Y1 - 2010

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AB - Pre-aggregated non-amyloid component of alpha-synuclein, NAC(61-95), was injected bilaterally into the CA3 area of rat hippocampus and behaviour was assessed using an alternating-lever cyclic-ratio (ALCR) schedule of operant responding. Four groups of rats were used (n=6 per group), subgroups were treated orally with either ibuprofen (40mg/kg) or vehicle (10 sucrose) twice daily. Intrahippocampal injection of NAC(61-95) increased lever switching errors and numbers of activated astrocytes, and ibuprofen treatment alleviated these effects.

UR - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19931572

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DO - 10.1016/j.bbr.2009.11.027

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EP - 277

JO - Behavioural Brain Research

JF - Behavioural Brain Research

IS - 1

ER -

Behavioural deterioration induced by intrahippocampal NAC61-95 injections and attenuation with ibuprofen

Abstract

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