Abstract
Pre-aggregated non-amyloid component of alpha-synuclein, NAC(61-95), was injected bilaterally into the CA3 area of rat hippocampus and behaviour was assessed using an alternating-lever cyclic-ratio (ALCR) schedule of operant responding. Four groups of rats were used (n=6 per group), subgroups were treated orally with either ibuprofen (40mg/kg) or vehicle (10 sucrose) twice daily. Intrahippocampal injection of NAC(61-95) increased lever switching errors and numbers of activated astrocytes, and ibuprofen treatment alleviated these effects.
Original language | English |
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Pages (from-to) | 274 - 277 |
Number of pages | 4 |
Journal | Behavioural Brain Research |
Volume | 208 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2010 |
Externally published | Yes |