Abstract
Pre-aggregated non-amyloid component of alpha-synuclein, NAC(61-95), was injected bilaterally into the CA3 area of rat hippocampus and behaviour was assessed using an alternating-lever cyclic-ratio (ALCR) schedule of operant responding. Four groups of rats were used (n=6 per group), subgroups were treated orally with either ibuprofen (40mg/kg) or vehicle (10 sucrose) twice daily. Intrahippocampal injection of NAC(61-95) increased lever switching errors and numbers of activated astrocytes, and ibuprofen treatment alleviated these effects.
| Original language | English |
|---|---|
| Pages (from-to) | 274 - 277 |
| Number of pages | 4 |
| Journal | Behavioural Brain Research |
| Volume | 208 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2010 |
| Externally published | Yes |
Cite this
O'Hare, E., Elliott, J. J., Hobson, P., Spanswick, D. C., & Kim, E-M. (2010). Behavioural deterioration induced by intrahippocampal NAC61-95 injections and attenuation with ibuprofen. Behavioural Brain Research, 208(1), 274 - 277. https://doi.org/10.1016/j.bbr.2009.11.027