BDNF Val66Met, A(Beta) amyloid, and cognitive decline in preclinical Alzheimer's disease

Yen Ying Lim, Victor L Villemagne, Simon M Laws, David J Ames, Robert H Pietrzak, Kathryn A Ellis, Karra D Harrington, Pierrick Bourgeat, Olivier Salvado, David Gordon Darby, Peter J Snyder, Ashley I Bush, Ralph N Martins, Colin Louis Masters, Christopher C Rowe, Pradeep Jonathan Nathan, Paul M Maruff

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Abstract

Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism has previously been implicated in Alzheimer s disease (AD)-related cognitive impairment. We aimed to determine the relationship between BDNF Val66Met and beta-amyloid (A?) on cognitive decline, hippocampal atrophy, and A? accumulation over 36 months in 165 healthy adults enrolled in the Australian Imaging, Biomarkers and Lifestyle study.
Original languageEnglish
Pages (from-to)2457-2464
Number of pages8
JournalNeurobiology of Aging
Volume34
Issue number11
DOIs
Publication statusPublished - 2013

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