BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases

Bai Lu, Guhan Nagappan, Xiaoming Guan, Pradeep J. Nathan, Paul Wren

Research output: Contribution to journalReview ArticleResearchpeer-review

363 Citations (Scopus)

Abstract

Increasing evidence suggests that synaptic dysfunction is a key pathophysiological hallmark in neurodegenerative disorders, including Alzheimer's disease. Understanding the role of brain-derived neurotrophic factor (BDNF) in synaptic plasticity and synaptogenesis, the impact of the BDNF Val66Met polymorphism in Alzheimer's disease-relevant endophenotypes-including episodic memory and hippocampal volume-and the technological progress in measuring synaptic changes in humans all pave the way for a 'synaptic repair' therapy for neurodegenerative diseases that targets pathophysiology rather than pathogenesis. This article reviews the key issues in translating BDNF biology into synaptic repair therapies.

Original languageEnglish
Pages (from-to)401-416
Number of pages16
JournalNature Reviews Neuroscience
Volume14
Issue number6
DOIs
Publication statusPublished - Jun 2013
Externally publishedYes

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