BCL2 in breast cancer: a favourable prognostic marker across molecular subtypes and independent of adjuvant therapy received

Sarah-Jane Dawson; Nikitsa Makretsov; Fiona Blows; Kristy Driver; Elena Provenzano; John Le Quesne; Laura Baglietto; Gianluca Severi; Graham Giles; Catriona Ann McLean; Grace Callagy; Andrew Green; Ian Ellis; Karen Gelmon; Gulisa Turashvili; S Leung; S Aparcio; David Huntsman; Carlos Caldas; Paul Pharoah

doi:10.1038/sj.bjc.6605736

BCL2 in breast cancer: a favourable prognostic marker across molecular subtypes and independent of adjuvant therapy received

Sarah-Jane Dawson, Nikitsa Makretsov, Fiona Blows, Kristy Driver, Elena Provenzano, John Le Quesne, Laura Baglietto, Gianluca Severi, Graham Giles, Catriona Ann McLean, Grace Callagy, Andrew Green, Ian Ellis, Karen Gelmon, Gulisa Turashvili, S Leung, S Aparcio, David Huntsman, Carlos Caldas, Paul Pharoah

Medicine Alfred Hospital

Research output: Contribution to journal › Article › Research › peer-review

187 Citations (Scopus)

Abstract

Five studies of 11 212 women with early-stage breast cancer were analysed. Individual patient data included tumour size, grade, lymph node status, endocrine therapy, chemotherapy and mortality. BCL2, ER, progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) levels were determined in all tumours. A Cox model incorporating the time-dependent effects of each variable was used to explore the prognostic significance of BCL2.

Original language	English
Pages (from-to)	668 - 675
Number of pages	8
Journal	British Journal of Cancer
Volume	103
Issue number	5
DOIs	https://doi.org/10.1038/sj.bjc.6605736
Publication status	Published - 2010

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Dawson, S-J., Makretsov, N., Blows, F., Driver, K., Provenzano, E., Le Quesne, J., Baglietto, L., Severi, G., Giles, G., McLean, C. A., Callagy, G., Green, A., Ellis, I., Gelmon, K., Turashvili, G., Leung, S., Aparcio, S., Huntsman, D., Caldas, C., & Pharoah, P. (2010). BCL2 in breast cancer: a favourable prognostic marker across molecular subtypes and independent of adjuvant therapy received. British Journal of Cancer, 103(5), 668 - 675. https://doi.org/10.1038/sj.bjc.6605736

Dawson, Sarah-Jane ; Makretsov, Nikitsa ; Blows, Fiona ; Driver, Kristy ; Provenzano, Elena ; Le Quesne, John ; Baglietto, Laura ; Severi, Gianluca ; Giles, Graham ; McLean, Catriona Ann ; Callagy, Grace ; Green, Andrew ; Ellis, Ian ; Gelmon, Karen ; Turashvili, Gulisa ; Leung, S ; Aparcio, S ; Huntsman, David ; Caldas, Carlos ; Pharoah, Paul. / BCL2 in breast cancer: a favourable prognostic marker across molecular subtypes and independent of adjuvant therapy received. In: British Journal of Cancer. 2010 ; Vol. 103, No. 5. pp. 668 - 675.

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abstract = "Five studies of 11 212 women with early-stage breast cancer were analysed. Individual patient data included tumour size, grade, lymph node status, endocrine therapy, chemotherapy and mortality. BCL2, ER, progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) levels were determined in all tumours. A Cox model incorporating the time-dependent effects of each variable was used to explore the prognostic significance of BCL2.",

author = "Sarah-Jane Dawson and Nikitsa Makretsov and Fiona Blows and Kristy Driver and Elena Provenzano and {Le Quesne}, John and Laura Baglietto and Gianluca Severi and Graham Giles and McLean, {Catriona Ann} and Grace Callagy and Andrew Green and Ian Ellis and Karen Gelmon and Gulisa Turashvili and S Leung and S Aparcio and David Huntsman and Carlos Caldas and Paul Pharoah",

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Dawson, S-J, Makretsov, N, Blows, F, Driver, K, Provenzano, E, Le Quesne, J, Baglietto, L, Severi, G, Giles, G , McLean, CA, Callagy, G, Green, A, Ellis, I, Gelmon, K, Turashvili, G, Leung, S, Aparcio, S, Huntsman, D, Caldas, C & Pharoah, P 2010, 'BCL2 in breast cancer: a favourable prognostic marker across molecular subtypes and independent of adjuvant therapy received', British Journal of Cancer, vol. 103, no. 5, pp. 668 - 675. https://doi.org/10.1038/sj.bjc.6605736

BCL2 in breast cancer: a favourable prognostic marker across molecular subtypes and independent of adjuvant therapy received. / Dawson, Sarah-Jane; Makretsov, Nikitsa; Blows, Fiona; Driver, Kristy; Provenzano, Elena; Le Quesne, John; Baglietto, Laura; Severi, Gianluca; Giles, Graham ; McLean, Catriona Ann; Callagy, Grace; Green, Andrew; Ellis, Ian; Gelmon, Karen; Turashvili, Gulisa; Leung, S; Aparcio, S; Huntsman, David; Caldas, Carlos; Pharoah, Paul.

In: British Journal of Cancer, Vol. 103, No. 5, 2010, p. 668 - 675.

Research output: Contribution to journal › Article › Research › peer-review

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AU - Gelmon, Karen

AU - Turashvili, Gulisa

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AU - Caldas, Carlos

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