Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets

Simone M. Schoenwaelder; Kate E. Jarman; Elizabeth E. Gardiner; My Hua; Jianlin Qiao; Michael J. White; Emma C. Josefsson; Imala Alwis; Akiko Ono; Abbey Willcox; Robert K. Andrews; Kylie D. Mason; Hatem H. Salem; David C. S. Huang; Benjamin T. Kile; Andrew W. Roberts; Shaun P. Jackson

doi:10.1182/blood-2011-04-347849

Bcl-x_L-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets

Simone M. Schoenwaelder, Kate E. Jarman, Elizabeth E. Gardiner, My Hua, Jianlin Qiao, Michael J. White, Emma C. Josefsson, Imala Alwis, Akiko Ono, Abbey Willcox, Robert K. Andrews, Kylie D. Mason, Hatem H. Salem, David C. S. Huang, Benjamin T. Kile, Andrew W. Roberts, Shaun P. Jackson

Australian Centre for Blood Diseases

Research output: Contribution to journal › Article › Research › peer-review

274 Citations (Scopus)

Abstract

Overall, these studies demonstrate that Bcl-xL-inhibitory BH3 mimetics not only induce thrombocytopenia, but also a transient thrombocytopathy that can undermine the hemostatic function of platelets

Original language	English
Pages (from-to)	1663-1674
Number of pages	12
Journal	Blood
Volume	118
Issue number	6
DOIs	https://doi.org/10.1182/blood-2011-04-347849
Publication status	Published - 2011

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10.1182/blood-2011-04-347849

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Schoenwaelder, S. M., Jarman, K. E., Gardiner, E. E., Hua, M., Qiao, J., White, M. J., Josefsson, E. C., Alwis, I., Ono, A., Willcox, A., Andrews, R. K., Mason, K. D., Salem, H. H., Huang, D. C. S., Kile, B. T., Roberts, A. W., & Jackson, S. P. (2011). Bcl-x_L-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets. Blood, 118(6), 1663-1674. https://doi.org/10.1182/blood-2011-04-347849

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title = "Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets",

abstract = "Overall, these studies demonstrate that Bcl-xL-inhibitory BH3 mimetics not only induce thrombocytopenia, but also a transient thrombocytopathy that can undermine the hemostatic function of platelets",

author = "Schoenwaelder, {Simone M.} and Jarman, {Kate E.} and Gardiner, {Elizabeth E.} and My Hua and Jianlin Qiao and White, {Michael J.} and Josefsson, {Emma C.} and Imala Alwis and Akiko Ono and Abbey Willcox and Andrews, {Robert K.} and Mason, {Kylie D.} and Salem, {Hatem H.} and Huang, {David C. S.} and Kile, {Benjamin T.} and Roberts, {Andrew W.} and Jackson, {Shaun P.}",

year = "2011",

doi = "10.1182/blood-2011-04-347849",

language = "English",

volume = "118",

pages = "1663--1674",

journal = "Blood",

issn = "0006-4971",

publisher = "American Society of Hematology",

number = "6",

}

Schoenwaelder, SM, Jarman, KE, Gardiner, EE, Hua, M, Qiao, J, White, MJ, Josefsson, EC, Alwis, I, Ono, A, Willcox, A, Andrews, RK, Mason, KD, Salem, HH, Huang, DCS, Kile, BT, Roberts, AW & Jackson, SP 2011, 'Bcl-x_L-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets', Blood, vol. 118, no. 6, pp. 1663-1674. https://doi.org/10.1182/blood-2011-04-347849

TY - JOUR

T1 - Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets

AU - Schoenwaelder, Simone M.

AU - Jarman, Kate E.

AU - Gardiner, Elizabeth E.

AU - Hua, My

AU - Qiao, Jianlin

AU - White, Michael J.

AU - Josefsson, Emma C.

AU - Alwis, Imala

AU - Ono, Akiko

AU - Willcox, Abbey

AU - Andrews, Robert K.

AU - Mason, Kylie D.

AU - Salem, Hatem H.

AU - Huang, David C. S.

AU - Kile, Benjamin T.

AU - Roberts, Andrew W.

AU - Jackson, Shaun P.

PY - 2011

Y1 - 2011

N2 - Overall, these studies demonstrate that Bcl-xL-inhibitory BH3 mimetics not only induce thrombocytopenia, but also a transient thrombocytopathy that can undermine the hemostatic function of platelets

AB - Overall, these studies demonstrate that Bcl-xL-inhibitory BH3 mimetics not only induce thrombocytopenia, but also a transient thrombocytopathy that can undermine the hemostatic function of platelets

UR - http://bloodjournal.hematologylibrary.org/content/118/6/1663

U2 - 10.1182/blood-2011-04-347849

DO - 10.1182/blood-2011-04-347849

M3 - Article

SN - 0006-4971

VL - 118

SP - 1663

EP - 1674

JO - Blood

JF - Blood

IS - 6

ER -

Bcl-x_L-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets

Abstract

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Other files and links

Molecular regulation of blood cell production and function

Investigation of a new platelet contractile mechanism regulating thrombus stability

The molecular regulation of platelet life span.

Cite this

Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets

Abstract

Access to Document

Other files and links

Projects

Molecular regulation of blood cell production and function

Investigation of a new platelet contractile mechanism regulating thrombus stability

The molecular regulation of platelet life span.

Cite this

Bcl-x_L-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets