Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets

Simone M. Schoenwaelder, Kate E. Jarman, Elizabeth E. Gardiner, My Hua, Jianlin Qiao, Michael J. White, Emma C. Josefsson, Imala Alwis, Akiko Ono, Abbey Willcox, Robert K. Andrews, Kylie D. Mason, Hatem H. Salem, David C. S. Huang, Benjamin T. Kile, Andrew W. Roberts, Shaun P. Jackson

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139 Citations (Scopus)

Abstract

Overall, these studies demonstrate that Bcl-xL-inhibitory BH3 mimetics not only induce thrombocytopenia, but also a transient thrombocytopathy that can undermine the hemostatic function of platelets
Original languageEnglish
Pages (from-to)1663-1674
Number of pages12
JournalBlood
Volume118
Issue number6
DOIs
Publication statusPublished - 2011

Cite this

Schoenwaelder, S. M., Jarman, K. E., Gardiner, E. E., Hua, M., Qiao, J., White, M. J., Josefsson, E. C., Alwis, I., Ono, A., Willcox, A., Andrews, R. K., Mason, K. D., Salem, H. H., Huang, D. C. S., Kile, B. T., Roberts, A. W., & Jackson, S. P. (2011). Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets. Blood, 118(6), 1663-1674. https://doi.org/10.1182/blood-2011-04-347849