Background: In children with cystic fibrosis (CF), tobramycin concentrations are monitored via the area under the plasma concentration time curve (AUC) approach. Currently, a minimum of 2 plasma concentrations of tobramycin within one dosing interval are required to estimate the AUC, which is costly, painful and blood collection is often difficult to coordinate. Aim: To evaluate the accuracy of tobramycin AUC estimated using 1 plasma concentration compared to AUC based on 2 plasma concentrations calculated using Bayesian software.
|Pages (from-to)||183 - 187|
|Number of pages||5|
|Journal||Journal of Pharmacy Practice and Research|
|Publication status||Published - 2011|