Bayesian optimisation of tobramycin dosing in paediatric patients with cystic fibrosis

Michael Barras, Hana Alraman, Carl Kirkpatrick, Margaret Harris, Carolyn Dakin, Katrina Jess, Melissa Pilbeam, Ross Norris

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Abstract

Background: In children with cystic fibrosis (CF), tobramycin concentrations are monitored via the area under the plasma concentration time curve (AUC) approach. Currently, a minimum of 2 plasma concentrations of tobramycin within one dosing interval are required to estimate the AUC, which is costly, painful and blood collection is often difficult to coordinate. Aim: To evaluate the accuracy of tobramycin AUC estimated using 1 plasma concentration compared to AUC based on 2 plasma concentrations calculated using Bayesian software.
Original languageEnglish
Pages (from-to)183 - 187
Number of pages5
JournalJournal of Pharmacy Practice and Research
Volume41
Issue number3
Publication statusPublished - 2011

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