Basement membranes in development and disease

Fenny Wiradjaja, Tia Marie Ditommaso, Ian Macleod Smyth

Research output: Contribution to journalArticleOther

35 Citations (Scopus)

Abstract

Basement membranes (BMs) are specializations of the extracellular matrix that act as key mediators of development and disease. Their sheet like protein matrices typically serve to separate epithelial or endothelial cell layers from underlying mesenchymal tissues, providing both a biophysical support to overlying tissue as well as a hub to promote and regulate cell-cell and cell-protein interactions. In the latter context, the BM is increasingly being recognized as a mediator of growth factor interactions during development. In this review, we discuss recent findings regarding the structure of the BM and its roles in mediating the normal development of the embryo, and we examine congenital diseases affecting the BM which impact embryonic development and health in later life.
Original languageEnglish
Pages (from-to)8 - 31
Number of pages24
JournalBirth Defects Research Part C: Embryo Today Reviews
Volume90
Issue number1
DOIs
Publication statusPublished - 2010

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