Base pairing of cytosine analogues with adenine and guanine in oligonucleotide duplexes: Evidence for exchange between Watson-Crick and wobble base pairs using 1H NMR spectroscopy

Angus N.R. Nedderman, Martin J. Stone, Paul Kong Thoo Lin, Daniel M. Brown, Dudley H. Williams

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)


1H NMR spectra of oligodeoxynucleotide duplexes incorporating N4-methoxycytosine and a related analogue paired with adenine and guanine demonstrate that Watson-Crick and wobble base pairs are in slow exchange on the chemical shift timescale.

Original languageEnglish
Pages (from-to)1357-1359
Number of pages3
JournalJournal of the Chemical Society, Chemical Communications
Issue number19
Publication statusPublished - 1991
Externally publishedYes

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