Base pairing of cytosine analogues with adenine and guanine in oligonucleotide duplexes

Evidence for exchange between Watson-Crick and wobble base pairs using 1H NMR spectroscopy

Angus N.R. Nedderman, Martin J. Stone, Paul Kong Thoo Lin, Daniel M. Brown, Dudley H. Williams

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Abstract

1H NMR spectra of oligodeoxynucleotide duplexes incorporating N4-methoxycytosine and a related analogue paired with adenine and guanine demonstrate that Watson-Crick and wobble base pairs are in slow exchange on the chemical shift timescale.

Original languageEnglish
Pages (from-to)1357-1359
Number of pages3
JournalJournal of the Chemical Society, Chemical Communications
Issue number19
DOIs
Publication statusPublished - 1991
Externally publishedYes

Cite this

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title = "Base pairing of cytosine analogues with adenine and guanine in oligonucleotide duplexes: Evidence for exchange between Watson-Crick and wobble base pairs using 1H NMR spectroscopy",
abstract = "1H NMR spectra of oligodeoxynucleotide duplexes incorporating N4-methoxycytosine and a related analogue paired with adenine and guanine demonstrate that Watson-Crick and wobble base pairs are in slow exchange on the chemical shift timescale.",
author = "Nedderman, {Angus N.R.} and Stone, {Martin J.} and Lin, {Paul Kong Thoo} and Brown, {Daniel M.} and Williams, {Dudley H.}",
year = "1991",
doi = "10.1039/C39910001357",
language = "English",
pages = "1357--1359",
journal = "Journal of the Chemical Society - Series Chemical Communications",
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publisher = "The Royal Society of Chemistry",
number = "19",

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Base pairing of cytosine analogues with adenine and guanine in oligonucleotide duplexes : Evidence for exchange between Watson-Crick and wobble base pairs using 1H NMR spectroscopy. / Nedderman, Angus N.R.; Stone, Martin J.; Lin, Paul Kong Thoo; Brown, Daniel M.; Williams, Dudley H.

In: Journal of the Chemical Society, Chemical Communications, No. 19, 1991, p. 1357-1359.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Stone, Martin J.

AU - Lin, Paul Kong Thoo

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AU - Williams, Dudley H.

PY - 1991

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JO - Journal of the Chemical Society - Series Chemical Communications

JF - Journal of the Chemical Society - Series Chemical Communications

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