Basal Progenitors Contribute to Repair of the Prostate Epithelium Following Induced Luminal Anoikis

Roxanne Toivanen, Adithi Mohan, Michael M Shen

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Contact with the extracellular matrix is essential for maintenance of epithelial cells in many tissues, while in its absence epithelial cells can detach and undergo anoikis. Here, we show that anoikis of luminal cells in the prostate epithelium is followed by a program of tissue repair that is mediated in part by differentiation of basal epithelial cells to luminal cells. We describe a mouse model in which inducible deletion of E-cadherin in prostate luminal cells results in their apoptotic cell death by anoikis, in the absence of phenotypic effects in the surrounding stroma. Quantitative assessments of proliferation and cell death in the luminal and basal compartments indicate that basal cells can rapidly generate luminal cells. Thus, our findings identify a role for basal-to-luminal differentiation in prostate epithelial repair, and provide a normal context to analogous processes that may occur during prostate cancer initiation.

Original languageEnglish
Pages (from-to)660-667
Number of pages8
JournalStem Cell Reports
Volume6
Issue number5
DOIs
Publication statusPublished - 10 May 2016
Externally publishedYes

Keywords

  • anoikis
  • epithelial lineage
  • prostate
  • stem cells
  • tissue repair

Cite this

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Basal Progenitors Contribute to Repair of the Prostate Epithelium Following Induced Luminal Anoikis. / Toivanen, Roxanne; Mohan, Adithi; Shen, Michael M.

In: Stem Cell Reports, Vol. 6, No. 5, 10.05.2016, p. 660-667.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Mohan, Adithi

AU - Shen, Michael M

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