Barriers and strategies to achieve a cure for HIV

Matthew C. Pitman, Jillian S.Y. Lau, James H. McMahon, Sharon R. Lewin

Research output: Contribution to journalReview ArticleResearchpeer-review

27 Citations (Scopus)

Abstract

9 years since the report of a cure for HIV after C-C chemokine receptor type 5 Δ32 stem cell transplantation, no other case of HIV cure has been reported, despite much research. However, substantial progress has been made in understanding the biology of the latent HIV reservoir, and in measuring the amount of virus that persists after antiretroviral therapy (ART) with increasingly sophisticated approaches. This knowledge is being translated into a long pipeline of clinical trials seeking to reduce viral persistence in participants on suppressive treatment and ultimately to allow safe cessation of ART. In this Review, we discuss the main barriers preventing the development of an HIV cure, methods used to measure HIV persistence in individuals on ART, clinical strategies that aim to cure HIV, and future directions for studies in the field of HIV cure research.

Original languageEnglish
Pages (from-to)e317-e328
Number of pages12
JournalThe Lancet HIV
Volume5
Issue number6
DOIs
Publication statusPublished - 1 Jun 2018

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