Barrett's esophagus: Cancer and molecular biology

Michael K. Gibson, Arashinder S. Dhaliwal, Nicholas J Clemons, Wayne A. Phillips, Katerina Dvorak, Daniel Tong, Simon Law, E. Daniel Pirchi, Jari Räsänen, Mark J. Krasna, Kaushal Parikh, Kausilia K. Krishnadath, Yu Chen, Leonard Griffiths, Benjamin J. Colleypriest, J. Mark Farrant, David Tosh, Kiron M. Das, Manisha Bajpai

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23 Citations (Scopus)

Abstract

The following paper on the molecular biology of Barrett's esophagus (BE) includes commentaries on signaling pathways central to the development of BE including Hh, NF-κB, and IL-6/STAT3; surgical approaches for esophagectomy and classification of lesions by appropriate therapy; the debate over the merits of minimally invasive esophagectomy versus open surgery; outcomes for patients with pharyngolaryngoesophagectomy; the applications of neoadjuvant chemotherapy and chemoradiotherapy; animal models examining the surgical models of BE and esophageal adenocarcinoma; the roles of various morphogens and Cdx2 in BE; and the use of in vitro BE models for chemoprevention studies.

Original languageEnglish
Pages (from-to)296-314
Number of pages19
JournalAnnals of the New York Academy of Sciences
Volume1300
Issue number1
DOIs
Publication statusPublished - Oct 2013
Externally publishedYes

Keywords

  • Barrett's esophagus
  • Esophageal adenocarcinoma
  • Esophagectomy
  • MIE

Cite this

Gibson, M. K., Dhaliwal, A. S., Clemons, N. J., Phillips, W. A., Dvorak, K., Tong, D., Law, S., Pirchi, E. D., Räsänen, J., Krasna, M. J., Parikh, K., Krishnadath, K. K., Chen, Y., Griffiths, L., Colleypriest, B. J., Farrant, J. M., Tosh, D., Das, K. M., & Bajpai, M. (2013). Barrett's esophagus: Cancer and molecular biology. Annals of the New York Academy of Sciences, 1300(1), 296-314. https://doi.org/10.1111/nyas.12252