Barcode-like paper sensor for smartphone diagnostics: An application of blood typing

Liyun Guan, Junfei Tian, Rong R Cao, Miaosi Li, ZhaoXiang Cai, Wei Shen

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

Abstract

This study introduced a barcode-like design into a paper-based blood typing device by integrating with smartphone-based technology. The concept of presenting a paper-based blood typing assay in a barcode-like pattern significantly enhanced the adaptability of the assay to the smartphone technology. The fabrication of this device involved the use of a printing technique to define hydrophilic bar channels which were, respectively, treated with Anti-A, -B, and -D antibodies. These channels were then used to perform blood typing assays by introducing a blood sample. Blood type can be visually identified from eluting lengths in bar channels. A smartphone-based analytical application was designed to read the bar channels, analogous to scanning a barcode, interpret this information, and then report results to users. The proposed paper-based blood typing device is rapidly read by smartphones and easy for the user to operate. We envisage that the adaptation of paper-based devices to the widely accepted smartphone technology will increase the capability of paper-based diagnostics with rapid assay result interpretation, data storage, and transmission
Original languageEnglish
Pages (from-to)11362 - 11367
Number of pages6
JournalAnalytical Chemistry
Volume86
Issue number22
DOIs
Publication statusPublished - 2014

Cite this

Guan, Liyun ; Tian, Junfei ; Cao, Rong R ; Li, Miaosi ; Cai, ZhaoXiang ; Shen, Wei. / Barcode-like paper sensor for smartphone diagnostics: An application of blood typing. In: Analytical Chemistry. 2014 ; Vol. 86, No. 22. pp. 11362 - 11367.
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abstract = "This study introduced a barcode-like design into a paper-based blood typing device by integrating with smartphone-based technology. The concept of presenting a paper-based blood typing assay in a barcode-like pattern significantly enhanced the adaptability of the assay to the smartphone technology. The fabrication of this device involved the use of a printing technique to define hydrophilic bar channels which were, respectively, treated with Anti-A, -B, and -D antibodies. These channels were then used to perform blood typing assays by introducing a blood sample. Blood type can be visually identified from eluting lengths in bar channels. A smartphone-based analytical application was designed to read the bar channels, analogous to scanning a barcode, interpret this information, and then report results to users. The proposed paper-based blood typing device is rapidly read by smartphones and easy for the user to operate. We envisage that the adaptation of paper-based devices to the widely accepted smartphone technology will increase the capability of paper-based diagnostics with rapid assay result interpretation, data storage, and transmission",
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Barcode-like paper sensor for smartphone diagnostics: An application of blood typing. / Guan, Liyun; Tian, Junfei; Cao, Rong R; Li, Miaosi; Cai, ZhaoXiang; Shen, Wei.

In: Analytical Chemistry, Vol. 86, No. 22, 2014, p. 11362 - 11367.

Research output: Contribution to journalArticleResearchpeer-review

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AB - This study introduced a barcode-like design into a paper-based blood typing device by integrating with smartphone-based technology. The concept of presenting a paper-based blood typing assay in a barcode-like pattern significantly enhanced the adaptability of the assay to the smartphone technology. The fabrication of this device involved the use of a printing technique to define hydrophilic bar channels which were, respectively, treated with Anti-A, -B, and -D antibodies. These channels were then used to perform blood typing assays by introducing a blood sample. Blood type can be visually identified from eluting lengths in bar channels. A smartphone-based analytical application was designed to read the bar channels, analogous to scanning a barcode, interpret this information, and then report results to users. The proposed paper-based blood typing device is rapidly read by smartphones and easy for the user to operate. We envisage that the adaptation of paper-based devices to the widely accepted smartphone technology will increase the capability of paper-based diagnostics with rapid assay result interpretation, data storage, and transmission

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