Baloxavir treatment of oseltamivir-resistant influenza A/H1pdm09 in two immunocompromised patients

Nenad Macesic; Jennifer M. Laplante; Justin G. Aaron; Emily A. DiMango; Benjamin A. Miko; Marcus R. Pereira; Ran Reshef; Kirsten St. George

doi:10.1111/tid.13542

Baloxavir treatment of oseltamivir-resistant influenza A/H1pdm09 in two immunocompromised patients

Nenad Macesic, Jennifer M. Laplante, Justin G. Aaron, Emily A. DiMango, Benjamin A. Miko, Marcus R. Pereira, Ran Reshef, Kirsten St. George

Infectious Diseases

Research output: Contribution to journal › Article › Research › peer-review

15 Citations (Scopus)

Abstract

Few treatment options are available for oseltamivir-resistant influenza. It has been proposed that baloxavir can be effective in this setting due to its distinct mechanism of action but clinical experience is lacking for immunocompromised patients. We report two such cases treated with baloxavir after failure of oseltamivir and detection of oseltamivir resistance mutations. Baloxavir/zanamivir combination therapy was effective in one patient, but persistent viral shedding was noted with baloxavir monotherapy in the other patient.

Original language	English
Article number	e13542
Number of pages	5
Journal	Transplant Infectious Disease
Volume	23
Issue number	3
DOIs	https://doi.org/10.1111/tid.13542
Publication status	Published - Jun 2021

Keywords

CAR-T cell therapy
H275Y
lung transplant
lymphoma
neuraminidase inhibitor

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/tid.13542

Cite this

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title = "Baloxavir treatment of oseltamivir-resistant influenza A/H1pdm09 in two immunocompromised patients",

abstract = "Few treatment options are available for oseltamivir-resistant influenza. It has been proposed that baloxavir can be effective in this setting due to its distinct mechanism of action but clinical experience is lacking for immunocompromised patients. We report two such cases treated with baloxavir after failure of oseltamivir and detection of oseltamivir resistance mutations. Baloxavir/zanamivir combination therapy was effective in one patient, but persistent viral shedding was noted with baloxavir monotherapy in the other patient.",

keywords = "CAR-T cell therapy, H275Y, lung transplant, lymphoma, neuraminidase inhibitor",

author = "Nenad Macesic and Laplante, {Jennifer M.} and Aaron, {Justin G.} and DiMango, {Emily A.} and Miko, {Benjamin A.} and Pereira, {Marcus R.} and Ran Reshef and {St. George}, Kirsten",

year = "2021",

month = jun,

doi = "10.1111/tid.13542",

language = "English",

volume = "23",

journal = "Transplant Infectious Disease",

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T1 - Baloxavir treatment of oseltamivir-resistant influenza A/H1pdm09 in two immunocompromised patients

AU - Macesic, Nenad

AU - Laplante, Jennifer M.

AU - Aaron, Justin G.

AU - DiMango, Emily A.

AU - Miko, Benjamin A.

AU - Pereira, Marcus R.

AU - Reshef, Ran

AU - St. George, Kirsten

PY - 2021/6

Y1 - 2021/6

N2 - Few treatment options are available for oseltamivir-resistant influenza. It has been proposed that baloxavir can be effective in this setting due to its distinct mechanism of action but clinical experience is lacking for immunocompromised patients. We report two such cases treated with baloxavir after failure of oseltamivir and detection of oseltamivir resistance mutations. Baloxavir/zanamivir combination therapy was effective in one patient, but persistent viral shedding was noted with baloxavir monotherapy in the other patient.

AB - Few treatment options are available for oseltamivir-resistant influenza. It has been proposed that baloxavir can be effective in this setting due to its distinct mechanism of action but clinical experience is lacking for immunocompromised patients. We report two such cases treated with baloxavir after failure of oseltamivir and detection of oseltamivir resistance mutations. Baloxavir/zanamivir combination therapy was effective in one patient, but persistent viral shedding was noted with baloxavir monotherapy in the other patient.

KW - CAR-T cell therapy

KW - H275Y

KW - lung transplant

KW - lymphoma

KW - neuraminidase inhibitor

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DO - 10.1111/tid.13542

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SN - 1398-2273

VL - 23

JO - Transplant Infectious Disease

JF - Transplant Infectious Disease

IS - 3

M1 - e13542

ER -

Baloxavir treatment of oseltamivir-resistant influenza A/H1pdm09 in two immunocompromised patients

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Integrating genomic and artificial intelligence approaches to combat antimicrobial resistance

Genomic approaches for understanding resistance to polymyxins in carbapenem-resistant Enterobacteriaceae

Cite this

Baloxavir treatment of oseltamivir-resistant influenza A/H1pdm09 in two immunocompromised patients

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Projects

Integrating genomic and artificial intelligence approaches to combat antimicrobial resistance

Genomic approaches for understanding resistance to polymyxins in carbapenem-resistant Enterobacteriaceae

Cite this