Baloxavir treatment of oseltamivir-resistant influenza A/H1pdm09 in two immunocompromised patients

Nenad Macesic, Jennifer M. Laplante, Justin G. Aaron, Emily A. DiMango, Benjamin A. Miko, Marcus R. Pereira, Ran Reshef, Kirsten St. George

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Few treatment options are available for oseltamivir-resistant influenza. It has been proposed that baloxavir can be effective in this setting due to its distinct mechanism of action but clinical experience is lacking for immunocompromised patients. We report two such cases treated with baloxavir after failure of oseltamivir and detection of oseltamivir resistance mutations. Baloxavir/zanamivir combination therapy was effective in one patient, but persistent viral shedding was noted with baloxavir monotherapy in the other patient.

Original languageEnglish
Number of pages5
JournalTransplant Infectious Disease
DOIs
Publication statusAccepted/In press - 5 Dec 2020

Keywords

  • CAR-T cell therapy
  • H275Y
  • lung transplant
  • lymphoma
  • neuraminidase inhibitor

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