BAFF, APRIL and human B cell disorders

Stuart G. Tangye; Vanessa L. Bryant; Amanda K. Cuss; Kim L Good

doi:10.1016/j.smim.2006.04.004

BAFF, APRIL and human B cell disorders

Stuart G. Tangye, Vanessa L. Bryant, Amanda K. Cuss, Kim L Good

Research output: Contribution to journal › Review Article › Research › peer-review

171 Citations (Scopus)

Abstract

B cells require signals from multiple sources for their development from precursor cells, and differentiation into effector cells. BAFF has been identified as a critical regulator of B cell development and differentiation. Defects in the production of BAFF and/or expression of its receptors have been associated with a diverse array of human immunopathologies characterised by perturbed B cell function and behaviour, including autoimmunity, malignancy, and immunodeficiency. This review will discuss the role of BAFF in the pathogenesis of these human immune disorders. It will also highlight relevant differences between the function of BAFF in humans and mice and the impact of this on the therapeutic utility of BAFF antagonists in the treatment of different human diseases.

Original language	English
Pages (from-to)	305-317
Number of pages	13
Journal	Seminars in Immunology
Volume	18
Issue number	5
DOIs	https://doi.org/10.1016/j.smim.2006.04.004
Publication status	Published - Oct 2006
Externally published	Yes

Keywords

APRIL
Autoimmunity
BAFF
Human B cells
Immunodeficiency
Malignancy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.smim.2006.04.004

Cite this

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title = "BAFF, APRIL and human B cell disorders",

abstract = "B cells require signals from multiple sources for their development from precursor cells, and differentiation into effector cells. BAFF has been identified as a critical regulator of B cell development and differentiation. Defects in the production of BAFF and/or expression of its receptors have been associated with a diverse array of human immunopathologies characterised by perturbed B cell function and behaviour, including autoimmunity, malignancy, and immunodeficiency. This review will discuss the role of BAFF in the pathogenesis of these human immune disorders. It will also highlight relevant differences between the function of BAFF in humans and mice and the impact of this on the therapeutic utility of BAFF antagonists in the treatment of different human diseases.",

keywords = "APRIL, Autoimmunity, BAFF, Human B cells, Immunodeficiency, Malignancy",

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year = "2006",

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AU - Tangye, Stuart G.

AU - Bryant, Vanessa L.

AU - Cuss, Amanda K.

AU - Good, Kim L

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Y1 - 2006/10

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AB - B cells require signals from multiple sources for their development from precursor cells, and differentiation into effector cells. BAFF has been identified as a critical regulator of B cell development and differentiation. Defects in the production of BAFF and/or expression of its receptors have been associated with a diverse array of human immunopathologies characterised by perturbed B cell function and behaviour, including autoimmunity, malignancy, and immunodeficiency. This review will discuss the role of BAFF in the pathogenesis of these human immune disorders. It will also highlight relevant differences between the function of BAFF in humans and mice and the impact of this on the therapeutic utility of BAFF antagonists in the treatment of different human diseases.

KW - APRIL

KW - Autoimmunity

KW - BAFF

KW - Human B cells

KW - Immunodeficiency

KW - Malignancy

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M3 - Review Article

C2 - 16916610

AN - SCOPUS:33747819824

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EP - 317

JO - Seminars in Immunology

JF - Seminars in Immunology

SN - 1044-5323

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ER -

BAFF, APRIL and human B cell disorders

Abstract

Keywords

UN SDGs

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