Research output per year
Research output per year
Fernando Gordillo Altamirano, John H. Forsyth, Ruzeen Patwa, Xenia Kostoulias, Michael Trim, Dinesh Subedi, Stuart K. Archer, Faye C. Morris, Cody Oliveira, Luisa Kielty, Denis Korneev, Moira K. O’Bryan, Trevor J. Lithgow, Anton Y. Peleg, Jeremy J. Barr
Research output: Contribution to journal › Article › Research › peer-review
We characterized two bacteriophages, ΦFG02 and ΦCO01, against clinical isolates of Acinetobacter baumannii and established that the bacterial capsule is the receptor for these phages. Phage-resistant mutants harboured loss-of-function mutations in genes responsible for capsule biosynthesis, resulting in capsule loss and disruption of phage adsorption. The phage-resistant strains were resensitized to human complement, beta-lactam antibiotics and alternative phages and exhibited diminished fitness in vivo. Using a mouse model of A. baumannii infection, we showed that phage therapy was effective.
Original language | English |
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Pages (from-to) | 157-161 |
Number of pages | 5 |
Journal | Nature Microbiology |
Volume | 6 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 2021 |
Research output: Other contribution › Research
Australian Research Council (ARC)
31/12/13 → 16/07/19
Project: Research
22/03/22
1 Media contribution
Press/Media: Blogs, Podcasts and Social Media › Podcasts
12/01/21 → 28/01/21
5 items of Media coverage, 1 Media contribution
Press/Media: Research
Jeremy Barr & Fernando Gordillo Altamirano
13/01/21
1 Media contribution
Press/Media: Research