Abstract
Abstract- Purpose: Urinary tract infection (UTI) is a prevalent infection in children. Over the years, the sensitivity and antimicrobial resistance patterns against uropathogens causing this infection have continuously changed. Pediatricians need updated knowledge of the antimicrobial sensitivity and resistance patterns of common uropathogens to provide appropriate treatment. This study aimed to determine the spectrum of causative uropathogens’ antimicrobial sensitivity and resistance patterns in pediatric patients.
Methods: A single-center, cross-sectional study was conducted from February 2021 to January 2022 at the tertiary care hospital in Rangpur, Bangladesh’s northernmost division. A total of 200 children aged 0 months to 12 years with clinically suspected UTIs were enrolled in the study. Researchers reviewed the study participants’ medical records and sent the urine sample for routine and microscopic examination and culture sensitivity testing.
Results: Out of 200 children,94 (47%) were identified as having presumptive UTIs due to significant pyuria, and 58 (29%) were diagnosed with confirmed UTIs. Escherichia coli was the most isolated (62%) pathogen. Among gram-negative bacteria, Klebsiella species (15.5%) were the second most common, and Enterococcus faecalis species (8.62%) were the most common among gram-positive bacteria. Nitrofurantoin (97%) was highly sensitive, followed by ciprofloxacin (93%). On the other hand, cefixime (97%), cotrimoxazole (81%), amoxicillin (72%), aztreonam (72%), and ceftriaxone (67%) were highly resistant to uropathogens.
Conclusions: In Bangladesh’s northernmost regions, previously used amoxicillin and cephalosporin groups of drugs are no longer helpful in treating UTIs among children, as this study suggested nitrofurantoin and ciprofloxacin as the most appropriate antibiotics.
Methods: A single-center, cross-sectional study was conducted from February 2021 to January 2022 at the tertiary care hospital in Rangpur, Bangladesh’s northernmost division. A total of 200 children aged 0 months to 12 years with clinically suspected UTIs were enrolled in the study. Researchers reviewed the study participants’ medical records and sent the urine sample for routine and microscopic examination and culture sensitivity testing.
Results: Out of 200 children,94 (47%) were identified as having presumptive UTIs due to significant pyuria, and 58 (29%) were diagnosed with confirmed UTIs. Escherichia coli was the most isolated (62%) pathogen. Among gram-negative bacteria, Klebsiella species (15.5%) were the second most common, and Enterococcus faecalis species (8.62%) were the most common among gram-positive bacteria. Nitrofurantoin (97%) was highly sensitive, followed by ciprofloxacin (93%). On the other hand, cefixime (97%), cotrimoxazole (81%), amoxicillin (72%), aztreonam (72%), and ceftriaxone (67%) were highly resistant to uropathogens.
Conclusions: In Bangladesh’s northernmost regions, previously used amoxicillin and cephalosporin groups of drugs are no longer helpful in treating UTIs among children, as this study suggested nitrofurantoin and ciprofloxacin as the most appropriate antibiotics.
| Original language | English |
|---|---|
| Pages (from-to) | 5-14 |
| Number of pages | 10 |
| Journal | Global Journal of Medical Research F: Diseases |
| Volume | 23 |
| Issue number | 4 |
| Publication status | Published - 2023 |
Keywords
- Urinary tract infection
- Children
- Bacteriological profile
- Antibiotic sensitivity