TY - JOUR
T1 - Bacterial regulatory RNAs
T2 - complexity, function, and putative drug targeting
AU - Cheah, Hong-Leong
AU - Raabe, Carsten A.
AU - Lee, Li-Pin
AU - Rozhdestvensky, Timofey S.
AU - Citartan, Marimuthu
AU - Ahmed, Siti Aminah
AU - Tang, Thean-Hock
N1 - Funding Information:
THT was supported by the Research University Grant for Individual [RUI, Grant No.: 1001/CIPPT/811319], Fundamental Research Grant Scheme [FRGS, Grant No.: 203/CIPPT/ 6711510], Trans-Disciplinary Research Grant Scheme [TRGS, Grant No.: 203/CIPPT/6769003], and Long Term Research Grant Scheme [LRGS, Grant No.: 600-IRMI/LRGS 5/3 (0003/ 2016)]. SAA was supported by eScience Fund [Grant No.: 305/CIPPT/613237] and The Short-Term Research Grants (Grant No.: 304/CIPPT/6313232). LPL was supported by the Advanced Medical and Dental Institute (AMDI) Student Research Fund and the Ministry of Education through the Graduate Research Assistant Scheme and the MyPhD scholarship, respectively. CAR was supported by internal funds of the University of Mu€nster and the Brandenburg Medical School (MHB).
Funding Information:
THT was supported by the Research University Grant for Individual [RUI, Grant No.: 1001/CIPPT/811319], Fundamental Research Grant Scheme [FRGS, Grant No.: 203/CIPPT/6711510], Trans-Disciplinary Research Grant Scheme [TRGS, Grant No.: 203/CIPPT/6769003], and Long Term Research Grant Scheme [LRGS, Grant No.: 600-IRMI/LRGS 5/3 (0003/2016)]. SAA was supported by eScience Fund [Grant No.: 305/CIPPT/613237] and The Short-Term Research Grants (Grant No.: 304/CIPPT/6313232). LPL was supported by the Advanced Medical and Dental Institute (AMDI) Student Research Fund and the Ministry of Education through the Graduate Research Assistant Scheme and the MyPhD scholarship, respectively. CAR was supported by internal funds of the University of Münster and the Brandenburg Medical School (MHB). Carsten A. Raabe is member of the phi Club of the Münster Alliance for Infection Research. We would like to thank Jürgen Brosius and Dr. Ch’ng Ewe Seng for comments on an earlier version of the manuscript.
Publisher Copyright:
© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2018
Y1 - 2018
N2 - Over the past decade, RNA-deep sequencing has uncovered copious non-protein coding RNAs (npcRNAs) in bacteria. Many of them are key players in the regulation of gene expression, taking part in various regulatory circuits, such as metabolic responses to different environmental stresses, virulence, antibiotic resistance, and host-pathogen interactions. This has contributed to the high adaptability of bacteria to changing or even hostile environments. Their mechanisms include the regulation of transcriptional termination, modulation of translation, and alteration of messenger RNA (mRNA) stability, as well as protein sequestration. Here, the mechanisms of gene expression by regulatory bacterial npcRNAs are comprehensively reviewed and supplemented with well-characterized examples. This class of molecules and their mechanisms of action might be useful targets for the development of novel antibiotics.
AB - Over the past decade, RNA-deep sequencing has uncovered copious non-protein coding RNAs (npcRNAs) in bacteria. Many of them are key players in the regulation of gene expression, taking part in various regulatory circuits, such as metabolic responses to different environmental stresses, virulence, antibiotic resistance, and host-pathogen interactions. This has contributed to the high adaptability of bacteria to changing or even hostile environments. Their mechanisms include the regulation of transcriptional termination, modulation of translation, and alteration of messenger RNA (mRNA) stability, as well as protein sequestration. Here, the mechanisms of gene expression by regulatory bacterial npcRNAs are comprehensively reviewed and supplemented with well-characterized examples. This class of molecules and their mechanisms of action might be useful targets for the development of novel antibiotics.
KW - Bacterial non-protein coding RNAs
KW - cis- and trans-antisense transcription
KW - regulation of gene expression
UR - https://www.scopus.com/pages/publications/85051068772
U2 - 10.1080/10409238.2018.1473330
DO - 10.1080/10409238.2018.1473330
M3 - Review Article
C2 - 29793351
AN - SCOPUS:85051068772
SN - 1040-9238
VL - 53
SP - 335
EP - 355
JO - Critical Reviews in Biochemistry and Molecular Biology
JF - Critical Reviews in Biochemistry and Molecular Biology
IS - 4
ER -