Bacterial fatty acid synthesis: Effect of Tween 80 on antibiotic potency against Streptococcus agalactiae and methicillin-resistant Staphylococcus aureus

Dragan Krsta, Ka Uen Caron Ku, Ian Travers Crosby, Benvenuto Capuano, David Thomas Manallack

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Abstract

The effect of varying concentrations of Tween 80 on the antimicrobial potency of platensimycin and triclosan was investigated using both Streptococcus agalactiae (S. agalactiae) and methicillin-resistant Staphylococcus aureus (MRSA). In the presence of very low concentrations of Tween 80 (0.02 ) both platensimycin and triclosan were rendered ineffective against S. agalactiae. A linear concentration-dependence was found with the antimicrobial activity of triclosan against MRSA showing a loss in effectiveness with increasing concentrations of Tween 80. Platensimycin, on the other hand, demonstrated improved antibiotic activity at higher concentrations of Tween 80. The differential effects of these two agents have implications for the regulation of lipids in Gram positive organisms and the viability of bacterial fatty acid synthesis inhibitors as antibiotics.
Original languageEnglish
Pages (from-to)80 - 84
Number of pages5
JournalAnti-Infective Agents
Volume12
Issue number1
DOIs
Publication statusPublished - 2014

Cite this

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abstract = "The effect of varying concentrations of Tween 80 on the antimicrobial potency of platensimycin and triclosan was investigated using both Streptococcus agalactiae (S. agalactiae) and methicillin-resistant Staphylococcus aureus (MRSA). In the presence of very low concentrations of Tween 80 (0.02 ) both platensimycin and triclosan were rendered ineffective against S. agalactiae. A linear concentration-dependence was found with the antimicrobial activity of triclosan against MRSA showing a loss in effectiveness with increasing concentrations of Tween 80. Platensimycin, on the other hand, demonstrated improved antibiotic activity at higher concentrations of Tween 80. The differential effects of these two agents have implications for the regulation of lipids in Gram positive organisms and the viability of bacterial fatty acid synthesis inhibitors as antibiotics.",
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Bacterial fatty acid synthesis: Effect of Tween 80 on antibiotic potency against Streptococcus agalactiae and methicillin-resistant Staphylococcus aureus. / Krsta, Dragan; Ku, Ka Uen Caron; Crosby, Ian Travers; Capuano, Benvenuto; Manallack, David Thomas.

In: Anti-Infective Agents, Vol. 12, No. 1, 2014, p. 80 - 84.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Bacterial fatty acid synthesis: Effect of Tween 80 on antibiotic potency against Streptococcus agalactiae and methicillin-resistant Staphylococcus aureus

AU - Krsta, Dragan

AU - Ku, Ka Uen Caron

AU - Crosby, Ian Travers

AU - Capuano, Benvenuto

AU - Manallack, David Thomas

PY - 2014

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AB - The effect of varying concentrations of Tween 80 on the antimicrobial potency of platensimycin and triclosan was investigated using both Streptococcus agalactiae (S. agalactiae) and methicillin-resistant Staphylococcus aureus (MRSA). In the presence of very low concentrations of Tween 80 (0.02 ) both platensimycin and triclosan were rendered ineffective against S. agalactiae. A linear concentration-dependence was found with the antimicrobial activity of triclosan against MRSA showing a loss in effectiveness with increasing concentrations of Tween 80. Platensimycin, on the other hand, demonstrated improved antibiotic activity at higher concentrations of Tween 80. The differential effects of these two agents have implications for the regulation of lipids in Gram positive organisms and the viability of bacterial fatty acid synthesis inhibitors as antibiotics.

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DO - 10.2174/22113525113119990116

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