TY - JOUR
T1 - Bacterial fatty acid synthesis
T2 - effect of Tween 80 on antibiotic potency against Streptococcus agalactiae and methicillin-resistant Staphylococcus aureus
AU - Krsta, Dragan
AU - Ku, Ka Uen Caron
AU - Crosby, Ian Travers
AU - Capuano, Benvenuto
AU - Manallack, David Thomas
PY - 2014
Y1 - 2014
N2 - The effect of varying concentrations of Tween 80 on the antimicrobial potency of platensimycin and triclosan was investigated using both Streptococcus agalactiae (S. agalactiae) and methicillin-resistant Staphylococcus aureus (MRSA). In the presence of very low concentrations of Tween 80 (0.02 ) both platensimycin and triclosan were rendered ineffective against S. agalactiae. A linear concentration-dependence was found with the antimicrobial activity of triclosan against MRSA showing a loss in effectiveness with increasing concentrations of Tween 80. Platensimycin, on the other hand, demonstrated improved antibiotic activity at higher concentrations of Tween 80. The differential effects of these two agents have implications for the regulation of lipids in Gram positive organisms and the viability of bacterial fatty acid synthesis inhibitors as antibiotics.
AB - The effect of varying concentrations of Tween 80 on the antimicrobial potency of platensimycin and triclosan was investigated using both Streptococcus agalactiae (S. agalactiae) and methicillin-resistant Staphylococcus aureus (MRSA). In the presence of very low concentrations of Tween 80 (0.02 ) both platensimycin and triclosan were rendered ineffective against S. agalactiae. A linear concentration-dependence was found with the antimicrobial activity of triclosan against MRSA showing a loss in effectiveness with increasing concentrations of Tween 80. Platensimycin, on the other hand, demonstrated improved antibiotic activity at higher concentrations of Tween 80. The differential effects of these two agents have implications for the regulation of lipids in Gram positive organisms and the viability of bacterial fatty acid synthesis inhibitors as antibiotics.
U2 - 10.2174/22113525113119990116
DO - 10.2174/22113525113119990116
M3 - Article
SN - 2211-3525
VL - 12
SP - 80
EP - 84
JO - Anti-Infective Agents
JF - Anti-Infective Agents
IS - 1
ER -