Bacterial causes of empyema in children, Australia, 2007-2009

Roxanne Strachan, Anita Cornelius, Gwendolyn Gilbert, Tanya Gulliver, Andrew Martin, Tim McDonald, Gillian Nixon, Rob Roseby, Sarath Ranganathan, Hiran Selvadurai, Greg Smith, Manuel Soto-Martinez, Sadasivam Suresh, Laurel Teoh, Kiran Thapa, Claire Wainwright, Adam Jaffe

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

Abstract

An increase in the incidence of empyema worldwide could be related to invasive pneumococcal disease caused by emergent nonvaccine replacement serotypes. To determine bacterial pathogens and pneumococcal serotypes that cause empyema in children in Australia, we conducted a 2-year study of 174 children with empyema. Blood and pleural fluid samples were cultured, and pleural fluid was tested by PCR. Thirty-two (21.0 ) of 152 blood and 53 (33.1 ) of 160 pleural fluid cultures were positive for bacteria; Streptococcus pneumoniae was the most common organism identified. PCR identified S. pneumoniae in 74 (51.7 ) and other bacteria in 19 (13.1 ) of 145 pleural fluid specimens. Of 53 samples in which S. pneumoniae serotypes were identified, 2 (3.8 ) had vaccine-related and 51 (96.2 ) had nonvaccine serotypes; 19A (n = 20; 36.4 ), 3 (n = 18; 32.7 ), and 1 (n = 8; 14.5 ) were the most common. High proportions of nonvaccine serotypes suggest the need to broaden vaccine coverage.
Original languageEnglish
Pages (from-to)1839 - 1845
Number of pages7
JournalEmerging Infectious Diseases
Volume17
Issue number10
DOIs
Publication statusPublished - 2011

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