Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 830 - 840 |
| Number of pages | 11 |
| Journal | Circulation Research |
| Volume | 109 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2011 |
Cite this
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B1a B lymphocytes are atheroprotective by secreting natural IgM that increases IgM deposits and reduces necrotic cores in atherosclerotic lesions. / Kyaw, Tin; Tay, Christopher; Krishnamurthi, Surendran; Kanellakis, Peter; Agrotis, Alexander; Tipping, Peter; Bobik, Alexander; Toh, Ban-Hock.
In: Circulation Research, Vol. 109, No. 8, 2011, p. 830 - 840.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - B1a B lymphocytes are atheroprotective by secreting natural IgM that increases IgM deposits and reduces necrotic cores in atherosclerotic lesions
AU - Kyaw, Tin
AU - Tay, Christopher
AU - Krishnamurthi, Surendran
AU - Kanellakis, Peter
AU - Agrotis, Alexander
AU - Tipping, Peter
AU - Bobik, Alexander
AU - Toh, Ban-Hock
PY - 2011
Y1 - 2011
N2 - Aggravated atherosclerosis in B lymphocyte-deficient chimeric mice and reduced atherosclerosis after transfer of unfractionated spleen B lymphocytes into splenectomized mice have led to the widely held notion that B lymphocytes are atheroprotective. However, B lymphocytes can be pathogenic, because their depletion by anti-CD20 antibody ameliorated atherosclerosis, and transfer of B2 lymphocytes aggravated atherosclerosis. These observations raise the question of the identity of the atheroprotective B-lymphocyte population. The purpose of the study was to identify an atheroprotective B-lymphocyte subset and mechanisms by which they confer atheroprotection.
AB - Aggravated atherosclerosis in B lymphocyte-deficient chimeric mice and reduced atherosclerosis after transfer of unfractionated spleen B lymphocytes into splenectomized mice have led to the widely held notion that B lymphocytes are atheroprotective. However, B lymphocytes can be pathogenic, because their depletion by anti-CD20 antibody ameliorated atherosclerosis, and transfer of B2 lymphocytes aggravated atherosclerosis. These observations raise the question of the identity of the atheroprotective B-lymphocyte population. The purpose of the study was to identify an atheroprotective B-lymphocyte subset and mechanisms by which they confer atheroprotection.
UR - http://circres.ahajournals.org/content/109/8/830.full.pdf+html
U2 - 10.1161/CIRCRESAHA.111.248542
DO - 10.1161/CIRCRESAHA.111.248542
M3 - Article
VL - 109
SP - 830
EP - 840
JO - Circulation Research
JF - Circulation Research
SN - 0009-7330
IS - 8
ER -