B1a B lymphocytes are atheroprotective by secreting natural IgM that increases IgM deposits and reduces necrotic cores in atherosclerotic lesions

Tin Kyaw, Christopher Tay, Surendran Krishnamurthi, Peter Kanellakis, Alexander Agrotis, Peter Tipping, Alexander Bobik, Ban-Hock Toh

Research output: Contribution to journalArticleResearchpeer-review

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Abstract

Aggravated atherosclerosis in B lymphocyte-deficient chimeric mice and reduced atherosclerosis after transfer of unfractionated spleen B lymphocytes into splenectomized mice have led to the widely held notion that B lymphocytes are atheroprotective. However, B lymphocytes can be pathogenic, because their depletion by anti-CD20 antibody ameliorated atherosclerosis, and transfer of B2 lymphocytes aggravated atherosclerosis. These observations raise the question of the identity of the atheroprotective B-lymphocyte population. The purpose of the study was to identify an atheroprotective B-lymphocyte subset and mechanisms by which they confer atheroprotection.
Original languageEnglish
Pages (from-to)830 - 840
Number of pages11
JournalCirculation Research
Volume109
Issue number8
DOIs
Publication statusPublished - 2011

Cite this

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title = "B1a B lymphocytes are atheroprotective by secreting natural IgM that increases IgM deposits and reduces necrotic cores in atherosclerotic lesions",
abstract = "Aggravated atherosclerosis in B lymphocyte-deficient chimeric mice and reduced atherosclerosis after transfer of unfractionated spleen B lymphocytes into splenectomized mice have led to the widely held notion that B lymphocytes are atheroprotective. However, B lymphocytes can be pathogenic, because their depletion by anti-CD20 antibody ameliorated atherosclerosis, and transfer of B2 lymphocytes aggravated atherosclerosis. These observations raise the question of the identity of the atheroprotective B-lymphocyte population. The purpose of the study was to identify an atheroprotective B-lymphocyte subset and mechanisms by which they confer atheroprotection.",
author = "Tin Kyaw and Christopher Tay and Surendran Krishnamurthi and Peter Kanellakis and Alexander Agrotis and Peter Tipping and Alexander Bobik and Ban-Hock Toh",
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pages = "830 -- 840",
journal = "Circulation Research",
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B1a B lymphocytes are atheroprotective by secreting natural IgM that increases IgM deposits and reduces necrotic cores in atherosclerotic lesions. / Kyaw, Tin; Tay, Christopher; Krishnamurthi, Surendran; Kanellakis, Peter; Agrotis, Alexander; Tipping, Peter; Bobik, Alexander; Toh, Ban-Hock.

In: Circulation Research, Vol. 109, No. 8, 2011, p. 830 - 840.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - B1a B lymphocytes are atheroprotective by secreting natural IgM that increases IgM deposits and reduces necrotic cores in atherosclerotic lesions

AU - Kyaw, Tin

AU - Tay, Christopher

AU - Krishnamurthi, Surendran

AU - Kanellakis, Peter

AU - Agrotis, Alexander

AU - Tipping, Peter

AU - Bobik, Alexander

AU - Toh, Ban-Hock

PY - 2011

Y1 - 2011

N2 - Aggravated atherosclerosis in B lymphocyte-deficient chimeric mice and reduced atherosclerosis after transfer of unfractionated spleen B lymphocytes into splenectomized mice have led to the widely held notion that B lymphocytes are atheroprotective. However, B lymphocytes can be pathogenic, because their depletion by anti-CD20 antibody ameliorated atherosclerosis, and transfer of B2 lymphocytes aggravated atherosclerosis. These observations raise the question of the identity of the atheroprotective B-lymphocyte population. The purpose of the study was to identify an atheroprotective B-lymphocyte subset and mechanisms by which they confer atheroprotection.

AB - Aggravated atherosclerosis in B lymphocyte-deficient chimeric mice and reduced atherosclerosis after transfer of unfractionated spleen B lymphocytes into splenectomized mice have led to the widely held notion that B lymphocytes are atheroprotective. However, B lymphocytes can be pathogenic, because their depletion by anti-CD20 antibody ameliorated atherosclerosis, and transfer of B2 lymphocytes aggravated atherosclerosis. These observations raise the question of the identity of the atheroprotective B-lymphocyte population. The purpose of the study was to identify an atheroprotective B-lymphocyte subset and mechanisms by which they confer atheroprotection.

UR - http://circres.ahajournals.org/content/109/8/830.full.pdf+html

U2 - 10.1161/CIRCRESAHA.111.248542

DO - 10.1161/CIRCRESAHA.111.248542

M3 - Article

VL - 109

SP - 830

EP - 840

JO - Circulation Research

JF - Circulation Research

SN - 0009-7330

IS - 8

ER -