B1a B lymphocytes are atheroprotective by secreting natural IgM that increases IgM deposits and reduces necrotic cores in atherosclerotic lesions

Tin Kyaw, Christopher Tay, Surendran Krishnamurthi, Peter Kanellakis, Alexander Agrotis, Peter Tipping, Alexander Bobik, Ban-Hock Toh

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193 Citations (Scopus)

Abstract

Aggravated atherosclerosis in B lymphocyte-deficient chimeric mice and reduced atherosclerosis after transfer of unfractionated spleen B lymphocytes into splenectomized mice have led to the widely held notion that B lymphocytes are atheroprotective. However, B lymphocytes can be pathogenic, because their depletion by anti-CD20 antibody ameliorated atherosclerosis, and transfer of B2 lymphocytes aggravated atherosclerosis. These observations raise the question of the identity of the atheroprotective B-lymphocyte population. The purpose of the study was to identify an atheroprotective B-lymphocyte subset and mechanisms by which they confer atheroprotection.
Original languageEnglish
Pages (from-to)830 - 840
Number of pages11
JournalCirculation Research
Volume109
Issue number8
DOIs
Publication statusPublished - 2011

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