B Cells and Antibody Production in Cancer

Jessica Da Gama Duarte; Elnaz Tavancheh; Luke Thomas Quigley; Simone Ostrouska; Andreas Behren

doi:10.1007/978-3-030-80962-1_4-1

B Cells and Antibody Production in Cancer

Jessica Da Gama Duarte, Elnaz Tavancheh, Luke Thomas Quigley, Simone Ostrouska, Andreas Behren

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review

Abstract

B cells and their products play a key role in the development and progression of cancers, with pro- and antitumoral functions in the tumor microenvironment and in circulation. This chapter summarizes the role of B cells in anti-tumor immune surveillance and malignant cell recognition, B cell origin and development, immunoglobulin gene rearrangement, isotypes and subclasses, elicitation of B cell immunity and B cell differentiation, cellular B cell immunity, and humoral immunity. Understanding B cell immunology is crucial to either promote or suppress B cell activity to favor tumor cell killing and explore novel therapeutic avenues for cancers.

Original language	English
Title of host publication	Handbook of Cancer and Immunology
Editors	Nima Rezaei
Place of Publication	Cham Switzerland
Publisher	Springer
Number of pages	20
Edition	Living
ISBN (Electronic)	9783030809621
ISBN (Print)	9783030809621
DOIs	https://doi.org/10.1007/978-3-030-80962-1_4-1
Publication status	Accepted/In press - 2024
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-3-030-80962-1_4-1

Cite this

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title = "B Cells and Antibody Production in Cancer",

abstract = "B cells and their products play a key role in the development and progression of cancers, with pro- and antitumoral functions in the tumor microenvironment and in circulation. This chapter summarizes the role of B cells in anti-tumor immune surveillance and malignant cell recognition, B cell origin and development, immunoglobulin gene rearrangement, isotypes and subclasses, elicitation of B cell immunity and B cell differentiation, cellular B cell immunity, and humoral immunity. Understanding B cell immunology is crucial to either promote or suppress B cell activity to favor tumor cell killing and explore novel therapeutic avenues for cancers.",

author = "{Da Gama Duarte}, Jessica and Elnaz Tavancheh and Quigley, {Luke Thomas} and Simone Ostrouska and Andreas Behren",

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AU - Quigley, Luke Thomas

AU - Ostrouska, Simone

AU - Behren, Andreas

PY - 2024

Y1 - 2024

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AB - B cells and their products play a key role in the development and progression of cancers, with pro- and antitumoral functions in the tumor microenvironment and in circulation. This chapter summarizes the role of B cells in anti-tumor immune surveillance and malignant cell recognition, B cell origin and development, immunoglobulin gene rearrangement, isotypes and subclasses, elicitation of B cell immunity and B cell differentiation, cellular B cell immunity, and humoral immunity. Understanding B cell immunology is crucial to either promote or suppress B cell activity to favor tumor cell killing and explore novel therapeutic avenues for cancers.

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DO - 10.1007/978-3-030-80962-1_4-1

M3 - Chapter (Book)

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