Axonal loss of retinal neurons in multiple sclerosis associated with optic radiation lesions

Alexander Klistorner, Prima Sriram, Nikitha Vootakuru, Chenyu Wang, Michael H. Barnett, Raymond Garrick, John Parratt, Netta Levin, Noa Raz, Anneke Van Der Walt, Lynette Masters, Stuart L. Graham, Con Yiannikas

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61 Citations (Scopus)

Abstract

Objective: To investigate the potential links between thinning of retinal ganglion cell axons in eyes of patients with multiple sclerosis (MS) without past optic neuritis (ON) and MS-related inflammatory damage of the posterior visual pathway. Methods: Temporal retinal nerve fiber layer (tRNFL) thickness was analyzed in eyes with no history of ON (NON) from 53 patients with relapsing-remitting MS. Fifty normal age- and sexmatched controls were examined with optical coherence tomography. Low-contrast visual acuity charts were used for functional assessment of vision. The optic tract (OT) and optic radiation (OR) were identified using probabilistic tractography, and volume of T2 fluid-attenuated inversion recovery lesions and diffusion tensor imaging (DTI) indices were measured within both structures. Cross-sectional diameter of the OT was also calculated. Results: tRNFL thickness was significantly reduced in NON eyes and was associated with reduced low-contrast visual acuity. Lesions within the OR were detected in the majority of patients. There was a significant correlation between thinning of the tRNFL and OR lesion volume (adjusted for non-OR lesion volume, age, sex, and disease duration). tRNFL thickness also correlated with OR DTI indices. No OT lesions were identified in any of the patients and no relationship between retinal nerve fiber layer loss and potential markers of OT lesions was found. Conclusion: The results demonstrate a strong tract-specific association between loss of tRNFL fibers and MS-related inflammation within OR.

Original languageEnglish
Pages (from-to)2165-2172
Number of pages8
JournalNeurology
Volume82
Issue number24
DOIs
Publication statusPublished - 17 Jun 2014
Externally publishedYes

Cite this

Klistorner, A., Sriram, P., Vootakuru, N., Wang, C., Barnett, M. H., Garrick, R., ... Yiannikas, C. (2014). Axonal loss of retinal neurons in multiple sclerosis associated with optic radiation lesions. Neurology, 82(24), 2165-2172. https://doi.org/10.1212/WNL.0000000000000522
Klistorner, Alexander ; Sriram, Prima ; Vootakuru, Nikitha ; Wang, Chenyu ; Barnett, Michael H. ; Garrick, Raymond ; Parratt, John ; Levin, Netta ; Raz, Noa ; Van Der Walt, Anneke ; Masters, Lynette ; Graham, Stuart L. ; Yiannikas, Con. / Axonal loss of retinal neurons in multiple sclerosis associated with optic radiation lesions. In: Neurology. 2014 ; Vol. 82, No. 24. pp. 2165-2172.
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abstract = "Objective: To investigate the potential links between thinning of retinal ganglion cell axons in eyes of patients with multiple sclerosis (MS) without past optic neuritis (ON) and MS-related inflammatory damage of the posterior visual pathway. Methods: Temporal retinal nerve fiber layer (tRNFL) thickness was analyzed in eyes with no history of ON (NON) from 53 patients with relapsing-remitting MS. Fifty normal age- and sexmatched controls were examined with optical coherence tomography. Low-contrast visual acuity charts were used for functional assessment of vision. The optic tract (OT) and optic radiation (OR) were identified using probabilistic tractography, and volume of T2 fluid-attenuated inversion recovery lesions and diffusion tensor imaging (DTI) indices were measured within both structures. Cross-sectional diameter of the OT was also calculated. Results: tRNFL thickness was significantly reduced in NON eyes and was associated with reduced low-contrast visual acuity. Lesions within the OR were detected in the majority of patients. There was a significant correlation between thinning of the tRNFL and OR lesion volume (adjusted for non-OR lesion volume, age, sex, and disease duration). tRNFL thickness also correlated with OR DTI indices. No OT lesions were identified in any of the patients and no relationship between retinal nerve fiber layer loss and potential markers of OT lesions was found. Conclusion: The results demonstrate a strong tract-specific association between loss of tRNFL fibers and MS-related inflammation within OR.",
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Klistorner, A, Sriram, P, Vootakuru, N, Wang, C, Barnett, MH, Garrick, R, Parratt, J, Levin, N, Raz, N, Van Der Walt, A, Masters, L, Graham, SL & Yiannikas, C 2014, 'Axonal loss of retinal neurons in multiple sclerosis associated with optic radiation lesions', Neurology, vol. 82, no. 24, pp. 2165-2172. https://doi.org/10.1212/WNL.0000000000000522

Axonal loss of retinal neurons in multiple sclerosis associated with optic radiation lesions. / Klistorner, Alexander; Sriram, Prima; Vootakuru, Nikitha; Wang, Chenyu; Barnett, Michael H.; Garrick, Raymond; Parratt, John; Levin, Netta; Raz, Noa; Van Der Walt, Anneke; Masters, Lynette; Graham, Stuart L.; Yiannikas, Con.

In: Neurology, Vol. 82, No. 24, 17.06.2014, p. 2165-2172.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Axonal loss of retinal neurons in multiple sclerosis associated with optic radiation lesions

AU - Klistorner, Alexander

AU - Sriram, Prima

AU - Vootakuru, Nikitha

AU - Wang, Chenyu

AU - Barnett, Michael H.

AU - Garrick, Raymond

AU - Parratt, John

AU - Levin, Netta

AU - Raz, Noa

AU - Van Der Walt, Anneke

AU - Masters, Lynette

AU - Graham, Stuart L.

AU - Yiannikas, Con

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N2 - Objective: To investigate the potential links between thinning of retinal ganglion cell axons in eyes of patients with multiple sclerosis (MS) without past optic neuritis (ON) and MS-related inflammatory damage of the posterior visual pathway. Methods: Temporal retinal nerve fiber layer (tRNFL) thickness was analyzed in eyes with no history of ON (NON) from 53 patients with relapsing-remitting MS. Fifty normal age- and sexmatched controls were examined with optical coherence tomography. Low-contrast visual acuity charts were used for functional assessment of vision. The optic tract (OT) and optic radiation (OR) were identified using probabilistic tractography, and volume of T2 fluid-attenuated inversion recovery lesions and diffusion tensor imaging (DTI) indices were measured within both structures. Cross-sectional diameter of the OT was also calculated. Results: tRNFL thickness was significantly reduced in NON eyes and was associated with reduced low-contrast visual acuity. Lesions within the OR were detected in the majority of patients. There was a significant correlation between thinning of the tRNFL and OR lesion volume (adjusted for non-OR lesion volume, age, sex, and disease duration). tRNFL thickness also correlated with OR DTI indices. No OT lesions were identified in any of the patients and no relationship between retinal nerve fiber layer loss and potential markers of OT lesions was found. Conclusion: The results demonstrate a strong tract-specific association between loss of tRNFL fibers and MS-related inflammation within OR.

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Klistorner A, Sriram P, Vootakuru N, Wang C, Barnett MH, Garrick R et al. Axonal loss of retinal neurons in multiple sclerosis associated with optic radiation lesions. Neurology. 2014 Jun 17;82(24):2165-2172. https://doi.org/10.1212/WNL.0000000000000522