Axon density and axon orientation dispersion in children born preterm

Claire E. Kelly, Deanne K. Thompson, Jian Chen, Alexander Leemans, Christopher L. Adamson, Terrie E. Inder, Jeanie L Y Cheong, Lex W. Doyle, Peter J. Anderson

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: Very preterm birth (VPT, <32 weeks' gestation) is associated with altered white matter fractional anisotropy (FA), the biological basis of which is uncertain but may relate to changes in axon density and/or dispersion, which can be measured using Neurite Orientation Dispersion and Density Imaging (NODDI). This study aimed to compare whole brain white matter FA, axon dispersion, and axon density between VPT children and controls (born ≥37 weeks' gestation), and to investigate associations with perinatal factors and neurodevelopmental outcomes. Methods: FA, neurite dispersion, and neurite density were estimated from multishell diffusion magnetic resonance images for 145 VPT and 33 control 7-year-olds. Diffusion values were compared between groups and correlated with perinatal factors (gestational age, birthweight, and neonatal brain abnormalities) and neurodevelopmental outcomes (IQ, motor, academic, and behavioral outcomes) using Tract-Based Spatial Statistics. Results: Compared with controls, VPT children had lower FA and higher axon dispersion within many major white matter fiber tracts. Neonatal brain abnormalities predicted lower FA and higher axon dispersion in many major tracts in VPT children. Lower FA, higher axon dispersion, and lower axon density in various tracts correlated with poorer neurodevelopmental outcomes in VPT children. Conclusions: FA and NODDI measures distinguished VPT children from controls and were associated with neonatal brain abnormalities and neurodevelopmental outcomes. This study provides a more detailed and biologically meaningful interpretation of white matter microstructure changes associated with prematurity. 

Original languageEnglish
Pages (from-to)3080-3102
Number of pages23
JournalHuman Brain Mapping
Volume37
Issue number9
DOIs
Publication statusPublished - Sep 2016

Keywords

  • diffusion tensor imaging
  • diffusion-weighted imaging
  • magnetic resonance imaging
  • neurodevelopment
  • NODDI
  • preterm birth
  • white matter

Cite this

Kelly, C. E., Thompson, D. K., Chen, J., Leemans, A., Adamson, C. L., Inder, T. E., ... Anderson, P. J. (2016). Axon density and axon orientation dispersion in children born preterm. Human Brain Mapping, 37(9), 3080-3102. https://doi.org/10.1002/hbm.23227
Kelly, Claire E. ; Thompson, Deanne K. ; Chen, Jian ; Leemans, Alexander ; Adamson, Christopher L. ; Inder, Terrie E. ; Cheong, Jeanie L Y ; Doyle, Lex W. ; Anderson, Peter J. / Axon density and axon orientation dispersion in children born preterm. In: Human Brain Mapping. 2016 ; Vol. 37, No. 9. pp. 3080-3102.
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Kelly, CE, Thompson, DK, Chen, J, Leemans, A, Adamson, CL, Inder, TE, Cheong, JLY, Doyle, LW & Anderson, PJ 2016, 'Axon density and axon orientation dispersion in children born preterm' Human Brain Mapping, vol. 37, no. 9, pp. 3080-3102. https://doi.org/10.1002/hbm.23227

Axon density and axon orientation dispersion in children born preterm. / Kelly, Claire E.; Thompson, Deanne K.; Chen, Jian; Leemans, Alexander; Adamson, Christopher L.; Inder, Terrie E.; Cheong, Jeanie L Y; Doyle, Lex W.; Anderson, Peter J.

In: Human Brain Mapping, Vol. 37, No. 9, 09.2016, p. 3080-3102.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Axon density and axon orientation dispersion in children born preterm

AU - Kelly, Claire E.

AU - Thompson, Deanne K.

AU - Chen, Jian

AU - Leemans, Alexander

AU - Adamson, Christopher L.

AU - Inder, Terrie E.

AU - Cheong, Jeanie L Y

AU - Doyle, Lex W.

AU - Anderson, Peter J.

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N2 - Background: Very preterm birth (VPT, <32 weeks' gestation) is associated with altered white matter fractional anisotropy (FA), the biological basis of which is uncertain but may relate to changes in axon density and/or dispersion, which can be measured using Neurite Orientation Dispersion and Density Imaging (NODDI). This study aimed to compare whole brain white matter FA, axon dispersion, and axon density between VPT children and controls (born ≥37 weeks' gestation), and to investigate associations with perinatal factors and neurodevelopmental outcomes. Methods: FA, neurite dispersion, and neurite density were estimated from multishell diffusion magnetic resonance images for 145 VPT and 33 control 7-year-olds. Diffusion values were compared between groups and correlated with perinatal factors (gestational age, birthweight, and neonatal brain abnormalities) and neurodevelopmental outcomes (IQ, motor, academic, and behavioral outcomes) using Tract-Based Spatial Statistics. Results: Compared with controls, VPT children had lower FA and higher axon dispersion within many major white matter fiber tracts. Neonatal brain abnormalities predicted lower FA and higher axon dispersion in many major tracts in VPT children. Lower FA, higher axon dispersion, and lower axon density in various tracts correlated with poorer neurodevelopmental outcomes in VPT children. Conclusions: FA and NODDI measures distinguished VPT children from controls and were associated with neonatal brain abnormalities and neurodevelopmental outcomes. This study provides a more detailed and biologically meaningful interpretation of white matter microstructure changes associated with prematurity. 

AB - Background: Very preterm birth (VPT, <32 weeks' gestation) is associated with altered white matter fractional anisotropy (FA), the biological basis of which is uncertain but may relate to changes in axon density and/or dispersion, which can be measured using Neurite Orientation Dispersion and Density Imaging (NODDI). This study aimed to compare whole brain white matter FA, axon dispersion, and axon density between VPT children and controls (born ≥37 weeks' gestation), and to investigate associations with perinatal factors and neurodevelopmental outcomes. Methods: FA, neurite dispersion, and neurite density were estimated from multishell diffusion magnetic resonance images for 145 VPT and 33 control 7-year-olds. Diffusion values were compared between groups and correlated with perinatal factors (gestational age, birthweight, and neonatal brain abnormalities) and neurodevelopmental outcomes (IQ, motor, academic, and behavioral outcomes) using Tract-Based Spatial Statistics. Results: Compared with controls, VPT children had lower FA and higher axon dispersion within many major white matter fiber tracts. Neonatal brain abnormalities predicted lower FA and higher axon dispersion in many major tracts in VPT children. Lower FA, higher axon dispersion, and lower axon density in various tracts correlated with poorer neurodevelopmental outcomes in VPT children. Conclusions: FA and NODDI measures distinguished VPT children from controls and were associated with neonatal brain abnormalities and neurodevelopmental outcomes. This study provides a more detailed and biologically meaningful interpretation of white matter microstructure changes associated with prematurity. 

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Kelly CE, Thompson DK, Chen J, Leemans A, Adamson CL, Inder TE et al. Axon density and axon orientation dispersion in children born preterm. Human Brain Mapping. 2016 Sep;37(9):3080-3102. https://doi.org/10.1002/hbm.23227