Averting inflammation by targeting the cytokine environment

Manfred Kopf, Martin F. Bachmann, Benjamin J. Marsland

Research output: Contribution to journalReview ArticleResearchpeer-review

159 Citations (Scopus)

Abstract

Cytokines are key instigators and regulators of immune responses and therefore hold great potential as targets for new therapeutic strategies. However, the selection of which cytokines to target, and in particular the identification of which cytokines regulate the rate-limiting steps of disease pathways, is crucial to the success of such strategies. Moreover, balancing the need for ablating pathological inflammatory responses and simultaneously maintaining the ability to control infectious agents is a key consideration. Recent advances in our understanding of cytokine networks, as well as technical progress in blocking cytokines in vivo, are likely to be a source for new drugs that can control chronic inflammatory diseases.

Original languageEnglish
Pages (from-to)703-718
Number of pages16
JournalNature Reviews Drug Discovery
Volume9
Issue number9
DOIs
Publication statusPublished - Sep 2010
Externally publishedYes

Cite this