Auxiliary-Directed C(sp3)−H Arylation by Synergistic Photoredox and Palladium Catalysis

Milena L. Czyz, David W. Lupton, Anastasios Polyzos

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14 Citations (Scopus)

Abstract

Herein we describe the auxiliary-directed arylation of unactivated C(sp3)−H bonds with aryldiazonium salts, which proceeds under synergistic photoredox and palladium catalysis. The site-selective arylation of aliphatic amides with α-quaternary centres is achieved with high selectivity for β-methyl C(sp3)−H bonds. This operationally simple method is compatible with carbocyclic amides, a range of aryldiazonium salts and proceeds at ambient conditions.

Original languageEnglish
Pages (from-to)14450-14453
Number of pages4
JournalChemistry - A European Journal
Volume23
Issue number58
DOIs
Publication statusPublished - 17 Oct 2017

Keywords

  • arylation
  • C−H activation
  • metallaphotoredox
  • palladium
  • photoredox

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