AUTORADIOGRAPHIC LOCALIZATION OF RECEPTORS IN THE MAMMALIAN CARDIOVASCULAR SYSTEM

SUMMARY 1. Autoradiographic techniques have been used to examine the location of β‐adrenoceptors in the heart and β‐adrenoceptors, substance P receptors and muscarinic cholinoceptors in blood vessels. 2. Both β₁‐adrenoceptors and β₂‐adrenoceptors were present in guinea‐pig and human heart, on the myocardium and associated with the cardiac nerves and blood vessels. 3. Nerves on the vasculature and vascular smooth muscle contained β‐adrenoceptors and muscarinic cholinoceptors. 4. Receptors for substance P and β‐adrenoceptors, but not muscarinic cholinoceptors were present on endothelial cells.