AUTORADIOGRAPHIC LOCALIZATION OF RECEPTORS IN THE MAMMALIAN CARDIOVASCULAR SYSTEM

R. J. Summers, P. Molenaar, J. A. Stephenson, C. R. Jones

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Abstract

SUMMARY 1. Autoradiographic techniques have been used to examine the location of β‐adrenoceptors in the heart and β‐adrenoceptors, substance P receptors and muscarinic cholinoceptors in blood vessels. 2. Both β1‐adrenoceptors and β2‐adrenoceptors were present in guinea‐pig and human heart, on the myocardium and associated with the cardiac nerves and blood vessels. 3. Nerves on the vasculature and vascular smooth muscle contained β‐adrenoceptors and muscarinic cholinoceptors. 4. Receptors for substance P and β‐adrenoceptors, but not muscarinic cholinoceptors were present on endothelial cells.

Original languageEnglish
Pages (from-to)437-447
Number of pages11
JournalClinical and Experimental Pharmacology and Physiology
Volume14
Issue number5
DOIs
Publication statusPublished - 1 Jan 1987

Keywords

  • autoradiography
  • guinea‐pig heart
  • human heart
  • muscarinic cholinoceptors
  • substance P.
  • β‐adrenoceptors

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