Autoradiographic localization of receptors in the cardiovascular system

R. J. Summers, P. Molenaar, J. A. Stephenson

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Examination by autoradiography of the anatomical relationships between receptors and the tissues they control demonstrates that cardiac β1-adrenoceptors are associated with the myocardium and specialized conducting and pacemaker regions. These areas also contain β2-adrenoceptors, which are in addition found in cardiac nerves, epicardium, and in association with the adventitial and intimai surfaces of the cardiac blood vessels. Studies of receptors associated with the vascular endothelium indicate at least two mechanisms whereby substances produce endothelium-dependent relaxation of smoth muscle. In the case of substance P, receptors are located on the endothelial cells, but for acctylcholirs the receptors are in the muscle, indicating that an intermediate step is involved in endothelium-dependent relaxation produced by this substance.

Original languageEnglish
Pages (from-to)272-276
Number of pages5
JournalTrends in Pharmacological Sciences
Issue number7
Publication statusPublished - 1 Jan 1987

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