Autoradiographic localization of β-adrenoceptors in rat kidney

Roger J. Summers; Michael J. Kuhar

doi:10.1016/0014-2999(83)90484-3

Autoradiographic localization of β-adrenoceptors in rat kidney

Roger J. Summers, Michael J. Kuhar

Research output: Contribution to journal › Article › Research › peer-review

31 Citations (Scopus)

Abstract

The β-adrenoceptor antagonist radioligand [¹²⁵I]cyanopindolol (CYP) has been used to localize β-adrenoceptors in rat kidney sections. [¹²⁵I]CYP bound with high affinity to sites in rat kidney sections having the recognition characteristics of β-adrenoceptors. Autoradiographic studies combined with histochemical techniques demonstrated that the β-adrenoceptors were primarily located on renal glomeruli, distal and cortical collecting tubules rather than on proximal tubules or vascular elements.

Original language	English
Pages (from-to)	305-310
Number of pages	6
Journal	European Journal of Pharmacology
Volume	91
Issue number	2-3
DOIs	https://doi.org/10.1016/0014-2999(83)90484-3
Publication status	Published - 22 Jul 1983

Keywords

Autoradiography
Rat kidney
[I]Cyanopindolol binding
β-Adrenoceptors

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10.1016/0014-2999(83)90484-3

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AB - The β-adrenoceptor antagonist radioligand [125I]cyanopindolol (CYP) has been used to localize β-adrenoceptors in rat kidney sections. [125I]CYP bound with high affinity to sites in rat kidney sections having the recognition characteristics of β-adrenoceptors. Autoradiographic studies combined with histochemical techniques demonstrated that the β-adrenoceptors were primarily located on renal glomeruli, distal and cortical collecting tubules rather than on proximal tubules or vascular elements.

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KW - Rat kidney

KW - [I]Cyanopindolol binding

KW - β-Adrenoceptors

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JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 2-3

ER -

Autoradiographic localization of β-adrenoceptors in rat kidney

Abstract

Keywords

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