Autophagy in immune defense against Mycobacterium tuberculosis

Isabelle Vergne, Sudha Singh, Esteban Roberts, George Kyei, Sharon Master, James Harris, Sergio De Haro, John Naylor, Alex Davis, Monica Delgado, Vojo Deretic

Research output: Contribution to journalReview ArticleResearchpeer-review

58 Citations (Scopus)

Abstract

Autophagy is a newly recognized innate and adaptive immunity defense against intracellular pathogens, in keeping with its role as a cytoplasmic maintenance pathway. Induction of autophagy by physiological, pharmacological or immunological means can eliminate intracellular Mycobacterium tuberculosis, providing one of the first examples of the immunological role of autophagy. Under normal circumstances, M. Tuberculosis survives in macrophages by inhibiting phagolysosome biogenesis. Induction of autophagy overcomes the mycobacterial phagosome maturation block, and delivers the tubercle bacilli to degradative compartments where they are eliminated.

Original languageEnglish
Pages (from-to)175-178
Number of pages4
JournalAutophagy
Volume2
Issue number3
Publication statusPublished - Jul 2006
Externally publishedYes

Keywords

  • Autophagosome
  • GTpase
  • Interferon
  • Phagosome
  • Phosphatidylinositol

Cite this