Autophagy is a cellular quality control process by which cytoplasmic constituents including proteins, protein aggregates, organelles, and invading pathogens can be delivered to lysosomes for degradation. Autophagy is activated in response to changes in the internal status of the cell and/or changes in the extracellular environment. It is therefore essential for the maintenance of cellular homeostasis and for an efficient response to cellular stresses. As such autophagy has been implicated either in the pathogenesis, or response to a wide variety of diseases, bacterial, and viral infections, and ageing.
|Title of host publication||Protein Misfolding and Cellular Stress in Disease and Aging: Concepts and Protocols|
|Editors||Peter Bross, Niels Gregersen|
|Place of Publication||UK|
|Pages||79 - 92|
|Number of pages||14|
|Publication status||Published - 2010|