Autophagy in Antigen Presentation

Christophe Macri, Justine D. Mintern

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Abstract

Macroautophagy (hereafter referred to as autophagy) is a eukaryotic catabolic pathway that eliminates intracellular contents and thereby provides cells with a source of nutrients. This fundamental pathway of cellular degradation also participates in immunity and inflammation. The capacity of autophagy to traffic, and to degrade, cytosolic protein is exploited by immune cells as a means to elicit antigen presentation. Here, we will summarize the current knowledge about the intersection of both classical and non-canonical autophagy with pathways of antigen presentation. While the role of autophagy in major histocompatibility complex class II (MHC II) presentation is well documented, autophagy is also implicated in endogenous MHC I presentation and MHC I cross-presentation. Thus, autophagy is a major effector of antigen presentation and has the capacity to impact host immunity and tolerance.
Original languageEnglish
Title of host publicationAutophagy networks in inflammation
EditorsMaria Chiara Maiuri, Daniela De Stefano
Place of PublicationSwitzerland
PublisherSpringer
Pages155-170
Number of pages16
ISBN (Electronic)9783319300795
ISBN (Print)9783319300771
DOIs
Publication statusPublished - Aug 2016
Externally publishedYes

Cite this

Macri, C., & Mintern, J. D. (2016). Autophagy in Antigen Presentation. In M. C. Maiuri, & D. De Stefano (Eds.), Autophagy networks in inflammation (pp. 155-170). Springer. https://doi.org/10.1007/978-3-319-30079-5_8