Abstract
| Original language | English |
|---|---|
| Title of host publication | Autophagy |
| Subtitle of host publication | Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging |
| Editors | M A Hayat |
| Place of Publication | Amsterdam |
| Publisher | Elsevier |
| Pages | 201-209 |
| Number of pages | 9 |
| Volume | 6 |
| ISBN (Print) | 978-0-12-801032-7 |
| DOIs | |
| Publication status | Published - 2015 |
Cite this
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Autophagy Controls the Production and Secretion of IL-1β : Underlying Mechanisms. / Peral de Castro, Celia; Jones, Sarah A; Harris, James.
Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging. ed. / M A Hayat. Vol. 6 Amsterdam : Elsevier, 2015. p. 201-209.Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review
TY - CHAP
T1 - Autophagy Controls the Production and Secretion of IL-1β
T2 - Underlying Mechanisms
AU - Peral de Castro, Celia
AU - Jones, Sarah A
AU - Harris, James
PY - 2015
Y1 - 2015
N2 - Although essential for the eradication of pathogens and tissue repair, inflammatory responses can be detrimental for the host when uncontrolled. Thus, the production of inflammatory mediators, including the proinflammatory cytokine IL-1β, must be tightly regulated to prevent excessive inflammation and collateral damage. Autophagy can regulate the production and secretion of the IL-1 cytokine family members IL-1α, IL-1β and IL-18, suggesting a pivotal role for autophagy in the regulation of inflammatory responses. This chapter focuses on the molecular mechanisms by which autophagy controls IL-1β secretion and addresses the relevance of this regulation in vitro and in vivo.
AB - Although essential for the eradication of pathogens and tissue repair, inflammatory responses can be detrimental for the host when uncontrolled. Thus, the production of inflammatory mediators, including the proinflammatory cytokine IL-1β, must be tightly regulated to prevent excessive inflammation and collateral damage. Autophagy can regulate the production and secretion of the IL-1 cytokine family members IL-1α, IL-1β and IL-18, suggesting a pivotal role for autophagy in the regulation of inflammatory responses. This chapter focuses on the molecular mechanisms by which autophagy controls IL-1β secretion and addresses the relevance of this regulation in vitro and in vivo.
UR - http://www.sciencedirect.com.ezproxy.lib.monash.edu.au/science/article/pii/B9780128010327000137
U2 - 10.1016/B978-0-12-801032-7.00013-7
DO - 10.1016/B978-0-12-801032-7.00013-7
M3 - Chapter (Book)
SN - 978-0-12-801032-7
VL - 6
SP - 201
EP - 209
BT - Autophagy
A2 - Hayat, M A
PB - Elsevier
CY - Amsterdam
ER -