Autophagy Controls the Production and Secretion of IL-1β: Underlying Mechanisms

Celia Peral de Castro, Sarah A Jones, James Harris

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Abstract

Although essential for the eradication of pathogens and tissue repair, inflammatory responses can be detrimental for the host when uncontrolled. Thus, the production of inflammatory mediators, including the proinflammatory cytokine IL-1β, must be tightly regulated to prevent excessive inflammation and collateral damage. Autophagy can regulate the production and secretion of the IL-1 cytokine family members IL-1α, IL-1β and IL-18, suggesting a pivotal role for autophagy in the regulation of inflammatory responses. This chapter focuses on the molecular mechanisms by which autophagy controls IL-1β secretion and addresses the relevance of this regulation in vitro and in vivo.
Original languageEnglish
Title of host publicationAutophagy
Subtitle of host publicationCancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging
EditorsM A Hayat
Place of PublicationAmsterdam
PublisherElsevier
Pages201-209
Number of pages9
Volume6
ISBN (Print)978-0-12-801032-7
DOIs
Publication statusPublished - 2015

Cite this