Autophagy and the immune response to TB

James Harris, Jayne C Hope, Ed C Lavelle

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Autophagy is a homeostatic mechanism for the catabolism of cytosolic constituents, including organelles, in times of stress and nutrient deprivation. In addition, autophagy has been linked to innate and adaptive immune responses to numerous infectious microorganisms, including mycobacteria. This review explores the role of autophagy in the responses of antigen-presenting cells to mycobacteria, including links with phagosome maturation, inflammasome activation and antigen presentation. In addition, the modulation of autophagy by cytokines and pathogen-derived stimuli is discussed.
Original languageEnglish
Pages (from-to)248 - 254
Number of pages7
JournalTransboundary and Emerging Diseases
Volume56
Issue number6-7
DOIs
Publication statusPublished - 2009

Cite this

Harris, James ; Hope, Jayne C ; Lavelle, Ed C. / Autophagy and the immune response to TB. In: Transboundary and Emerging Diseases. 2009 ; Vol. 56, No. 6-7. pp. 248 - 254.
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Autophagy and the immune response to TB. / Harris, James; Hope, Jayne C; Lavelle, Ed C.

In: Transboundary and Emerging Diseases, Vol. 56, No. 6-7, 2009, p. 248 - 254.

Research output: Contribution to journalArticleResearchpeer-review

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AB - Autophagy is a homeostatic mechanism for the catabolism of cytosolic constituents, including organelles, in times of stress and nutrient deprivation. In addition, autophagy has been linked to innate and adaptive immune responses to numerous infectious microorganisms, including mycobacteria. This review explores the role of autophagy in the responses of antigen-presenting cells to mycobacteria, including links with phagosome maturation, inflammasome activation and antigen presentation. In addition, the modulation of autophagy by cytokines and pathogen-derived stimuli is discussed.

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