TY - JOUR
T1 - Autophagy and the immune response to TB
AU - Harris, James
AU - Hope, Jayne C
AU - Lavelle, Ed C
PY - 2009
Y1 - 2009
N2 - Autophagy is a homeostatic mechanism for the catabolism of cytosolic constituents, including organelles, in times of stress and nutrient deprivation. In addition, autophagy has been linked to innate and adaptive immune responses to numerous infectious microorganisms, including mycobacteria. This review explores the role of autophagy in the responses of antigen-presenting cells to mycobacteria, including links with phagosome maturation, inflammasome activation and antigen presentation. In addition, the modulation of autophagy by cytokines and pathogen-derived stimuli is discussed.
AB - Autophagy is a homeostatic mechanism for the catabolism of cytosolic constituents, including organelles, in times of stress and nutrient deprivation. In addition, autophagy has been linked to innate and adaptive immune responses to numerous infectious microorganisms, including mycobacteria. This review explores the role of autophagy in the responses of antigen-presenting cells to mycobacteria, including links with phagosome maturation, inflammasome activation and antigen presentation. In addition, the modulation of autophagy by cytokines and pathogen-derived stimuli is discussed.
UR - http://www.ncbi.nlm.nih.gov/pubmed/19389082
U2 - 10.1111/j.1865-1682.2009.01069.x
DO - 10.1111/j.1865-1682.2009.01069.x
M3 - Article
SN - 1865-1674
VL - 56
SP - 248
EP - 254
JO - Transboundary and Emerging Diseases
JF - Transboundary and Emerging Diseases
IS - 6-7
ER -