Autophagy and IL-1 family cytokines

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Autophagy is an important intracellular homeostatic mechanism for the targeting of cytosolic constituents, including organelles, for lysosomal degradation. Autophagy plays roles in numerous physiological processes, including immune cell responses to endogenous and exogenous pathogenic stimuli. Moreover, autophagy has a potentially pivotal role to play in the regulation of inflammatory responses. In particular, autophagy regulates endogenous inflammasome activators, as well as inflammasome components and pro-IL-1beta. As a result, autophagy acts a key modulator of IL-1beta and IL-18, as well as IL-1alpha, release. This review focuses specifically on the role autophagy plays in regulating the production, processing, and secretion of IL-1 and IL-18 and the consequences of this important function.
Original languageEnglish
Pages (from-to)1 - 6
Number of pages6
JournalFrontiers in Immunology
Volume4
Issue numberArt. ID: 83
DOIs
Publication statusPublished - 2013

Cite this

Harris, James. / Autophagy and IL-1 family cytokines. In: Frontiers in Immunology. 2013 ; Vol. 4, No. Art. ID: 83. pp. 1 - 6.
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Autophagy and IL-1 family cytokines. / Harris, James.

In: Frontiers in Immunology, Vol. 4, No. Art. ID: 83, 2013, p. 1 - 6.

Research output: Contribution to journalArticleResearchpeer-review

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AB - Autophagy is an important intracellular homeostatic mechanism for the targeting of cytosolic constituents, including organelles, for lysosomal degradation. Autophagy plays roles in numerous physiological processes, including immune cell responses to endogenous and exogenous pathogenic stimuli. Moreover, autophagy has a potentially pivotal role to play in the regulation of inflammatory responses. In particular, autophagy regulates endogenous inflammasome activators, as well as inflammasome components and pro-IL-1beta. As a result, autophagy acts a key modulator of IL-1beta and IL-18, as well as IL-1alpha, release. This review focuses specifically on the role autophagy plays in regulating the production, processing, and secretion of IL-1 and IL-18 and the consequences of this important function.

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