Autonomic dysfunction in children with sleep disordered breathing

Lisa Mary Walter, Gillian Michelle Nixon, Margot J Davey, Vicki Anne Anderson, Adrian Mark Walker, Rosemary Sylvia Claire Horne

Research output: Contribution to journalArticleResearchpeer-review

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Abstract

PURPOSE: Sleep disordered breathing (SDB) has adverse effects on cardiovascular health in adults, partly due to changes in autonomic activity. However, there have been limited studies in children. We analysed the impact of SDB and sleep stage on autonomic control of heart rate in 7-12-year-old children, utilizing spectral heart rate variability (HRV) as a measure of autonomic activity. METHODS: Eighty children underwent overnight polysomnography. Subjects were grouped according to their obstructive apnoea-hypopnoea index (OAHI): controls, OAHI 5. HRV was analysed during Wake, nonrapid eye movement (NREM) 1 2, slow wave sleep (SWS) and REM. RESULTS: Compared with controls, total power, low (LF) and high frequency (HF) power were reduced in all SDB severities during REM. LF/HF ratio was less in MS SDB (median = 0.34; range, 0.20-0.49; p <0.05) versus controls (0.38; 0.26-0.55; p <0.05) and PS (0.39; 0.23-0.57; p <0.05) during SWS. In all groups, total power, LF and HF power were highest during NREM 1 2 while LF/HF ratio was lowest during SWS. Blood pressure was elevated in SDB in all sleep states. CONCLUSIONS: HRV was altered in 7-12-year-old children with SDB, which may signify an overall depression of autonomic tone, perhaps a consequence of their elevated blood pressure during sleep coupled with repeated exposure to SDB event-related cardiovascular disturbance. Further research is warranted to elucidate the long-term effects on the cardiovascular system of subjects exhibiting impaired HRV and elevated BP in childhood.
Original languageEnglish
Pages (from-to)605 - 613
Number of pages9
JournalSleep and Breathing
Volume17
Issue number2
DOIs
Publication statusPublished - 2013

Cite this

@article{433b953663f14fd8afb6121277389f45,
title = "Autonomic dysfunction in children with sleep disordered breathing",
abstract = "PURPOSE: Sleep disordered breathing (SDB) has adverse effects on cardiovascular health in adults, partly due to changes in autonomic activity. However, there have been limited studies in children. We analysed the impact of SDB and sleep stage on autonomic control of heart rate in 7-12-year-old children, utilizing spectral heart rate variability (HRV) as a measure of autonomic activity. METHODS: Eighty children underwent overnight polysomnography. Subjects were grouped according to their obstructive apnoea-hypopnoea index (OAHI): controls, OAHI 5. HRV was analysed during Wake, nonrapid eye movement (NREM) 1 2, slow wave sleep (SWS) and REM. RESULTS: Compared with controls, total power, low (LF) and high frequency (HF) power were reduced in all SDB severities during REM. LF/HF ratio was less in MS SDB (median = 0.34; range, 0.20-0.49; p <0.05) versus controls (0.38; 0.26-0.55; p <0.05) and PS (0.39; 0.23-0.57; p <0.05) during SWS. In all groups, total power, LF and HF power were highest during NREM 1 2 while LF/HF ratio was lowest during SWS. Blood pressure was elevated in SDB in all sleep states. CONCLUSIONS: HRV was altered in 7-12-year-old children with SDB, which may signify an overall depression of autonomic tone, perhaps a consequence of their elevated blood pressure during sleep coupled with repeated exposure to SDB event-related cardiovascular disturbance. Further research is warranted to elucidate the long-term effects on the cardiovascular system of subjects exhibiting impaired HRV and elevated BP in childhood.",
author = "Walter, {Lisa Mary} and Nixon, {Gillian Michelle} and Davey, {Margot J} and Anderson, {Vicki Anne} and Walker, {Adrian Mark} and Horne, {Rosemary Sylvia Claire}",
year = "2013",
doi = "10.1007/s11325-012-0727-x",
language = "English",
volume = "17",
pages = "605 -- 613",
journal = "Sleep and Breathing",
issn = "1520-9512",
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Autonomic dysfunction in children with sleep disordered breathing. / Walter, Lisa Mary; Nixon, Gillian Michelle; Davey, Margot J; Anderson, Vicki Anne; Walker, Adrian Mark; Horne, Rosemary Sylvia Claire.

In: Sleep and Breathing, Vol. 17, No. 2, 2013, p. 605 - 613.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Autonomic dysfunction in children with sleep disordered breathing

AU - Walter, Lisa Mary

AU - Nixon, Gillian Michelle

AU - Davey, Margot J

AU - Anderson, Vicki Anne

AU - Walker, Adrian Mark

AU - Horne, Rosemary Sylvia Claire

PY - 2013

Y1 - 2013

N2 - PURPOSE: Sleep disordered breathing (SDB) has adverse effects on cardiovascular health in adults, partly due to changes in autonomic activity. However, there have been limited studies in children. We analysed the impact of SDB and sleep stage on autonomic control of heart rate in 7-12-year-old children, utilizing spectral heart rate variability (HRV) as a measure of autonomic activity. METHODS: Eighty children underwent overnight polysomnography. Subjects were grouped according to their obstructive apnoea-hypopnoea index (OAHI): controls, OAHI 5. HRV was analysed during Wake, nonrapid eye movement (NREM) 1 2, slow wave sleep (SWS) and REM. RESULTS: Compared with controls, total power, low (LF) and high frequency (HF) power were reduced in all SDB severities during REM. LF/HF ratio was less in MS SDB (median = 0.34; range, 0.20-0.49; p <0.05) versus controls (0.38; 0.26-0.55; p <0.05) and PS (0.39; 0.23-0.57; p <0.05) during SWS. In all groups, total power, LF and HF power were highest during NREM 1 2 while LF/HF ratio was lowest during SWS. Blood pressure was elevated in SDB in all sleep states. CONCLUSIONS: HRV was altered in 7-12-year-old children with SDB, which may signify an overall depression of autonomic tone, perhaps a consequence of their elevated blood pressure during sleep coupled with repeated exposure to SDB event-related cardiovascular disturbance. Further research is warranted to elucidate the long-term effects on the cardiovascular system of subjects exhibiting impaired HRV and elevated BP in childhood.

AB - PURPOSE: Sleep disordered breathing (SDB) has adverse effects on cardiovascular health in adults, partly due to changes in autonomic activity. However, there have been limited studies in children. We analysed the impact of SDB and sleep stage on autonomic control of heart rate in 7-12-year-old children, utilizing spectral heart rate variability (HRV) as a measure of autonomic activity. METHODS: Eighty children underwent overnight polysomnography. Subjects were grouped according to their obstructive apnoea-hypopnoea index (OAHI): controls, OAHI 5. HRV was analysed during Wake, nonrapid eye movement (NREM) 1 2, slow wave sleep (SWS) and REM. RESULTS: Compared with controls, total power, low (LF) and high frequency (HF) power were reduced in all SDB severities during REM. LF/HF ratio was less in MS SDB (median = 0.34; range, 0.20-0.49; p <0.05) versus controls (0.38; 0.26-0.55; p <0.05) and PS (0.39; 0.23-0.57; p <0.05) during SWS. In all groups, total power, LF and HF power were highest during NREM 1 2 while LF/HF ratio was lowest during SWS. Blood pressure was elevated in SDB in all sleep states. CONCLUSIONS: HRV was altered in 7-12-year-old children with SDB, which may signify an overall depression of autonomic tone, perhaps a consequence of their elevated blood pressure during sleep coupled with repeated exposure to SDB event-related cardiovascular disturbance. Further research is warranted to elucidate the long-term effects on the cardiovascular system of subjects exhibiting impaired HRV and elevated BP in childhood.

UR - http://www.ncbi.nlm.nih.gov/pubmed/22684854

U2 - 10.1007/s11325-012-0727-x

DO - 10.1007/s11325-012-0727-x

M3 - Article

VL - 17

SP - 605

EP - 613

JO - Sleep and Breathing

JF - Sleep and Breathing

SN - 1520-9512

IS - 2

ER -